Slideshow

Where Separation Science is Heading: Quotes

Celebrating 25 Years of LCGC Cover
Quotes from leading separation scientists on the future of separation science and the challenges that must be addressed.

 

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Featured LCGC Interviews

The Future of Chromatographic Method Development in Pharma

Analytical chemists are always seeking to make method development more efficient. For nearly two decades, Chris Welch led his teams at the Merck & Co. to constantly drive innovation in this area. Following his recent retirement from the company last year, he and his colleagues wrote a paper about the current state of method development for pharmaceutical research and where it is heading. He recently spoke to us about this topic.

Analyzing Artificial Sweeteners as Environmental Contaminants

The Column spoke to Núria Fontanals, a senior researcher at the Department of Analytical and Organic Chemistry, Universitat Rovira i Virgili, Spain, discusses the role and application of HILIC–HRMS methods to analyse artificial sweeteners as emerging organic contaminants (EOCs).

Gas Chromatography

Injecting Water onto a GC Column: Solving the Mystery of Poor Chromatography

By Chris English

Ethylene glycol is a particularly difficult compound to analyze because it is not easily extracted from water. Many environmental samples originate from water runoff at airports, where ethylene glycol is used as a de‑icing agent for airplanes during winter months. Hydraulic fracturing is a technique where pressurized fluid and sand or other solids (proppant) are used in gas drilling to allow gas extraction. Glycols are a common ingredient in most hydraulic fracturing fluid and play a key role in preventing emulsifications and stabilizing the solutions. The direct aqueous injection of ethylene glycol is challenging because it can be difficult to attain reproducibility and good peak shape. The large expansion volume of water can cause backflash, carryover can cause inconsistent results, and excess water can extinguish the flame ionization detection (FID) flame. This article describes a robust approach to analyze glycols in aqueous samples, which reduces downtime and maintains sensitivity.

Trends and Developments

By LCGC Editors

A snapshot of key trends and developments in the chromatography sector according to selected panellists from companies who exhibited at Analytica 2018.

Mass Spectrometry

Headspace Solid-Phase Microextraction Coupled with Gas Chromatography–Mass Spectrometry for the Characterization of Polymeric Materials

By Peter Kusch

HS-SPME-GC–MS is a valuable technique for identifying volatile organic compounds, additives, and degradation products in industrial rubber, car labeling reflection foil, and bone cement materials.

Recent Advances in Comprehensive Chromatographic Analysis of Emerging Drugs

By Ira S. Lurie, Lauriane Tremeau-Cayel, Walter F. Rowe

To address the challenges of analyzing new illicit drugs, emerging techniques such as UHPSFC with MS and UV detection, and GC with VUV detection, may be needed, particularly for distinguishing positional isomers and diastereomers.

Sample Preparation

Trends and Developments

By LCGC Editors

A snapshot of key trends and developments in the chromatography sector according to selected panellists from companies who exhibited at Analytica 2018.

Recent Advances in Solid-Phase Microextraction, Part I: New Tricks for an Old Dog

By Douglas E. Raynie

A look at recent advances in SPME, such as increasing the sorbent surface area available for extraction, accommodating direct analysis by mass spectrometry, and sorbent overcoating to resist fouling by sugars and lipids

Partner Organizations

Chinese American Chromatography Association (CACA)

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ChromAcademy

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LCGC Blog

The LCGC Blog: A Weighty Problem with Calibration

By Tony Taylor

Chromatographic methods often require that the analyte response is calibrated (and validated) over a wide concentration range when the analyte concentration in the sample is either unknown or is expected to vary widely. Bioanalysis, environmental, and clinical applications are just a few examples of where this may be the case.

The LCGC Blog: Multipath Liquid Chromatography–Mass Spectrometry: A Veritable Pandora’s Box

By Kevin A. Schug

For several years, our group has been working on a concept that we have termed multipath liquid chromatography (LC). The main idea is to target multiple classes of compounds following a single injection of a sample, the components of which are segregated on-line and directed to separate appropriate paths for simultaneous separation; the streams are then recombined for detection. I believe that this approach would be powerful for biomarker quantitation, where it would be more informative to track both metabolite and protein biomarkers to better define a disease state, or in the case of antibody–drug conjugate (ADC) development, where the metabolism of the ADC might involve understanding both the levels of the released drug and the remaining protein.

Celebrating 35 Years

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Latest News

Calls for Nominations for 2019 CACA Student Excellence Awards

The Chinese American Chromatography Association (CACA) invites nominations for two awards.

Calls for Nominations for 2019 CACA Young Investigator Award

The Chinese American Chromatography Association (CACA) invites nominations for the 2019 CACA Young Investigator Award.

LCGC eBooks

Miniaturized Analytical Equipment Solves Key Challenges for Laboratories
Sometimes, great solutions for analytical laboratories come in small packages. This ebook highlights the important role that miniaturized instruments play in addressing challenges faced by laboratories.

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CHROMacademy

HPLC Mobile Phases – 10 bad habits to avoid

The 10 bad habits to avoid when producing HPLC mobile phases.

10 Ways to Break Your LC-MS

If there’s one mantra that’s essential for an LC (or GC)-MS operator it’s “contamination, contamination, contamination”. Keep contamination to a minimum and you’ll enjoy a reliable instrument; don’t take the necessary precautions and instead you’ll enjoy reaching for the vent switch and purchasing lots of spares.

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