Where Separation Science is Heading: Quotes

Celebrating 25 Years of LCGC Cover
Quotes from leading separation scientists on the future of separation science and the challenges that must be addressed.


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Featured LCGC Interviews

Determining Chloride and Sugars in Food Samples Using HPLC

Accurate quantification of sugars in saline solution is now possible using a new high performance liquid chromatography (HPLC) method. The Column spoke to Abdelrahman Saleh Zaky from the School of Biosciences at the University of Nottingham (Nottingham, UK) about this method.

Recent Developments in Microchip Electrophoresis

Capillary electrophoresis (CE) is routinely used for chemical and biochemical analysis methods, and recently the technique has been implemented on microchips. R. Scott Martin, a professor and chair of chemistry at Saint Louis University, has been investigating ways to improve these techniques for years. He recently spoke to us about his research coupling microchip electrophoresis with electrochemical detection, coupling continuous flow with microchip electrophoresis with valving, coupling microchip CE with microdialysis sampling and electrochemistry, and more.

Gas Chromatography

Results Correlation with External Influences

By John V. Hinshaw

When data change over time, you may be able to tease out the causes by conducting a time-series analysis or by looking at various forms of correlation.

The Secrets of Successful Temperature Programming

By Dawn Wallace Watson

A quick step-by-step guide for optimizing GC temperature programming.

Mass Spectrometry

Haloacetic Acid Analysis Using Two-Dimensional Matrix-Elimination Ion Chromatography

By Rong Lin, Herb Wagner, Carl Fisher, Kannan Srinivasan, Chris Pohl

The disinfectants commonly used to treat public drinking water can react with naturally occurring organic and inorganic matter in the source water to form disinfection byproducts such as haloacetic acids. Here, we describe the use of two-dimensional matrix-elimination ion chromatography (MEIC) for haloacetic acid analysis. This method minimizes the impact of matrix ions.

Evaluating Substance Use via Wastewater Analysis: An Overview of Analytical Workflows

By Frederic Been, Foon Yin Lai, Adrian Covaci, Alexander L.N. van Nuijs

Wastewater analysis has become an established approach for retrieving additional epidemiological information about the use of illicit drugs, alcohol, and tobacco at the population level. Here, we present an overview of the recent analytical frameworks and workflows for target and suspect analyses using low- and high-resolution mass spectrometry and discuss the latest advances in wastewater-based epidemiology (WBE).

Sample Preparation

The Analysis of Persistent Organic Pollutants Using Pressurized Liquid Extraction and Automated Column Chromatography Sample Cleanup

By Ruud Addink, Tom Hall

The persistent nature and toxicity of persistent organic pollutants (POPs) lead to high demands for quick and accurate sample analysis. This article describes the use of automated sample processing techniques such as pressurized liquid extraction and automated column chromatography cleanup that are suitable for environmental sample analysis.

Partner Organizations

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The LCGC Blog: Data Systems - Do You Know Where Your Results Come From?

By Tony Taylor

Data validity and a thorough understanding of the results that we produce should be of great interest to us all. Here's why.

The LCGC Blog: Potential for use of Stable Isotope–Labeled Internal Standards in Gas Chromatography–Vacuum Ultraviolet Spectroscopy Methods

By Kevin A. Schug

Internal standards (IS) are commonly incorporated into quantitative methods to increase accuracy and precision. An IS is a compound that is different than the analyte of interest, has similar physicochemical properties to the analyte, and is added to samples, calibration standards, and quality control samples in a known quantity. It should not be present in the sample, it should be available in high purity, and it should be easily differentiable from the analyte of interest.

Celebrating 35 Years




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Latest News

Restek Wins Company of the Year

Restek has been awarded company of the year by The Pennsylvania/Delaware Chapter of the ESOP Association during its annual conference on 14 September 2017.

New Mass Screening Approach for Algal Blooms

Researchers from The First Institute of Oceanography in Qingdao, China, have developed an exact mass suspect screening approach for identifying multiple lipophilic marine toxins in seawater, suspended particulate matter (SPM), and marine sediment using LC–TOF-MS.


Editors' Series: Modern Liquid Chromatographic Approaches for Successful Characterization of mAbs and Related Products

Tuesday, October 24th, 2017 

11:00 am EDT / 08:00 am PDT / 4:00 pm BST / 5:00 pm CEST

High-Throughput Aroma Analysis of Food Products Using Direct MS

Wednesday, October 25th, 2017 

Europe Broadcast:  2:00 pm BST / 3:00 pm CEST

US Broadcast: 2:00 pm EDT / 1:00 pm CDT / 11:00 am PDT

More Upcoming and On Demand Webcasts>>

LCGC eBooks

Advances in Biopharmaceutical Characterization
In this eBook, readers will gain insight into the evolution and future of Orbitrap-based mass spectrometry systems straight from the inventor of this technology, Alexander Makarov, PhD, director of global research LSMS at Thermo Fisher Scientific.

Go to eBook Library



HPLC Mobile Phases – 10 bad habits to avoid

The 10 bad habits to avoid when producing HPLC mobile phases.

10 Ways to Break Your LC-MS

If there’s one mantra that’s essential for an LC (or GC)-MS operator it’s “contamination, contamination, contamination”. Keep contamination to a minimum and you’ll enjoy a reliable instrument; don’t take the necessary precautions and instead you’ll enjoy reaching for the vent switch and purchasing lots of spares.

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