Industry: Chiral - Chromatography Online
Industry: Chiral

A Multimodal Liquid and Supercritical Fluid Chromatography Chiral Separation Screening and Column Maintenance Strategy Designed to Support Molecules in Pharmaceutical Development, Part II

September 1, 2013

The establishment of a system suitability plan that focuses on the maintenance of the most important variable in any chiral separation screen — the column — is presented.

Recent Progress in Chiral Stationary Phase Development and Current Chiral Applications

April 1, 2014

A review of chiral separations, which remain a decided area of interest, particularly in the pharmaceutical and agrochemical fields

The State of the Art in Chiral Capillary Gas Chromatography

May 1, 2012

A review of the historical development and latest trends in phase development in the field of chiral capillary gas chromatography. A range of novel applications in chiral capillary GC are also described.

Strategies for Rapid Chiral HPLC Method Development for Pharmaceutical Analysis

April 19, 2012

Automated column and mobile phase screening is the current trend in the pharmaceutical industry to develop chiral methods. This study presents comprehensive strategies for automated rapid chiral HPLC method development including normal-phase, reversed-phase and polar organic phase separation modes.

Recent Progress in Chiral Stationary Phase Development and Current Chiral Applications

April 1, 2012

update on some of the latest chiral stationary phases and their use in various separation modes

Chiral Stationary Phase Development

May 1, 2011

The development of chiral column technology since the review in 2008 is discussed by Thomas Beesley.

Chiral Analysis of Flavours and Fragrances

January 27, 2010

Design of a FID/MS Splitting for MS Detection in The First and Second Dimension of a Multidimensional GC–MS System

The Separation of Enantiomers on Modified Cyclodextrins by Capillary Electrochromatography (CEC)

February 1, 2009

Various modes of capillary electrochromatography (CEC) for the separation of enantiomers on immobilized cyclodextrin derivatives are described. The following techniques have been used: (i) open-tubular electrochromatography (o-CEC), (ii) packed electrochromatography (p-CEC) and (iii) monolithic electrochromatography (rod-CEC). Three different strategies to prepare enantioselective cyclodextrin-coated chiral monoliths are described. The advantages and disadvantages of the various methods are outlined.

3 μm Particle-Based Chiral Stationary Phases for the Fast and Efficient Resolution of Enantiomers

September 1, 2008

The move from conventional particle sizes (5 μm or higher) to smaller diameter packing materials is one of the most attractive approaches to achieve higher separating efficiency. Recently developed 3 μm polysaccharide-derived chiral stationary phases demonstrate characteristics of favourable mass transfer kinetics, high column efficiency and good column permeability. This allows the fast analysis of enantiomers using conventional HPLC instruments.

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LCGC COLUMNISTS 2014

Sample Prep Perspectives | Ronald E. Majors: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments.
LATEST: UV Detector Problems


Perspectives in Modern HPLC | Michael W. Dong: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: Superficially Porous Particles: Perspectives, Practices, and Trends


MS — The Practical Art | Kate Yu: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis


LC Troubleshooting | John Dolan: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: Problems with Large-Molecule Separations


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