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May 1, 2012
By:
Thomas Beesley, Ronald E. Majors
A review of the historical development and latest trends in phase development in the field of chiral capillary gas chromatography. A range of novel applications in chiral capillary GC are also described.
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April 19, 2012
By:
Kelly Ke Zhang, Midco Chi-Ying Tsang
Automated column and mobile phase screening is the current trend in the pharmaceutical industry to develop chiral methods. This study presents comprehensive strategies for automated rapid chiral HPLC method development including normal-phase, reversed-phase and polar organic phase separation modes.
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April 1, 2012
By:
Timothy J. Ward, Karen D. Ward
update on some of the latest chiral stationary phases and their use in various separation modes
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May 1, 2011
By:
Thomas E. Beesley
The development of chiral column technology since the review in 2008 is discussed by Thomas Beesley.
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January 27, 2010
Design of a FID/MS Splitting for MS Detection in The First and Second Dimension of a Multidimensional GC–MS System
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February 1, 2009
By:
Dorothee Witsuba, Volker Schurig
Various modes of capillary electrochromatography (CEC) for the separation of enantiomers on immobilized cyclodextrin derivatives are described. The following techniques have been used: (i) open-tubular electrochromatography (o-CEC), (ii) packed electrochromatography (p-CEC) and (iii) monolithic electrochromatography (rod-CEC). Three different strategies to prepare enantioselective cyclodextrin-coated chiral monoliths are described. The advantages and disadvantages of the various methods are outlined.
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September 1, 2008
The move from conventional particle sizes (5 μm or higher) to smaller diameter packing materials is one of the most attractive approaches to achieve higher separating efficiency. Recently developed 3 μm polysaccharide-derived chiral stationary phases demonstrate characteristics of favourable mass transfer kinetics, high column efficiency and good column permeability. This allows the fast analysis of enantiomers using conventional HPLC instruments.
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July 7, 2008
Professor Wolfgang Lindner from the Department of Analytical Chemistry and Food Chemistry at the University of Vienna, Austria, has been awarded the 2008 Chirality Medal in recognition of his achievements in the field of separation sciences and in particular stereoselective separation techniques.
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June 25, 2008
Chiral Technologies Europe offers a flexible custom separation service for preparative separation and purification of pharmaceutical lead compounds and intermediates.
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