Misc - Chromatography Online

LECO NA - Jet Fuel Analysis by High Resolution TOFMS

August 7, 2013

In this application note, the combination of chemical ionization (HR-CI) and standard electron ionization (EI) on the Pegasus GC-HRT (High Resolution TOFMS) provides an unparalleled analysis tool for jet fuel characterization. In particular, for labile branched chain alkanes, the confirmation of intact molecular ions is facilitated by HR-CI. Characterization of these branched species is vital to jet fuel producers.

LECO NA - High Resolution GC/MS Analysis of Drug Residues

June 19, 2013

High resolution mass spectrometry with soft ionization facilitates identification of unknown compounds which were present in extracted residues from a confiscated pipe. Comprehensive data acquisition allows for complete analysis of samples and a combination of high resolution EI and HR-CI data facilitates confident characterization of novel synthetic drugs.

Detecting Sulfur-Containing Metabolites of Asparagus in Urine by SBSE-GCxGC-TOFMS

June 17, 2013

In this study, the goal was to eliminate the use of potentially hazardous solvents and reduce overall extraction time through the use of GERSTEL's Twister Stir Bar Sorption Extraction (SBSE).

LECO NA - GCxGC-TOFMS of Metabolic Samples from Hybrid Aspen Plants

June 17, 2013

The GCxGC technique with the additional analytical separation gained by spectral deconvolution resulted in more than 400 peaks being found and identified in samples from hybrid aspen plants.

Screening for Metabolite Differences in Rat Plasma with GCxGC-TOFMS

June 17, 2013

This research shows a fast, efficient, and simple comparative analysis method for screening large sample pools to distinguish metabolite variations as potential biomarkers for healthy and disease state populations.

GC High Resolution TOFMS for Mouse Liver Metabolomic Analyses

June 17, 2013

LECO's Pegasus GC-HRT (High Resolution TOFMS) is applied to the identification and differential analysis of metabolites extracted for diseased livers from mice exposed to alcohol with and without fatty diets.

Analysis of Urine Samples Used for Liver Drug-Induced Injury Study

June 17, 2013

The objective of the study presented here is to develop a suite of toxicity markers from GC-TOFMS analysis, for use in pre-clinical screening of drug candidates.

Small Molecule Metabolite Identification in Diabetic Samples Using GCxGC-TOFMS

June 17, 2013

This diabetic versus non-diabetic research demonstrates that comprehensive two-dimensional gas chromatography combined with time-of-flight mass spectrometry (GCxGC-TOFMS) is ideal for identifying the small molecule metabolite profile in complex biological samples.

LECO NA - Statistical Variation in Metabolite Profiles of Fish Species

June 17, 2013

This research presents a step-by-step data mining approach using metabolomics data from two different fish species to demonstrate the value of the LECO ChromaTOF Statistical Compare feature.


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