Application Notes: LC/HPLC

Nov 15, 2017
Sponsored Content - EU
The distribution of insulin oligomers, a critical quality attribute for insulin drug product, is determined absolutely using multi-angle light scattering (SEC-MALS).
Nov 15, 2017
Sponsored Content - NA
The distribution of insulin oligomers, a critical quality attribute for insulin drug product, is determined absolutely using multi-angle light scattering (SEC-MALS).
Nov 08, 2017
Sponsored Content - NA
The TSKgel UP-SW3000 column provides excellent reproducibility of retention time, asymmetry, and column efficiency. As demonstrated by the %RSD values, injection-to injection reproducibility was superior to an evaluated competitor column.
Nov 08, 2017
Sponsored Content - NA
Isopropyl alcohol (IPA) does not alter the diffusion of mAbs using a TSKgel UP-SW3000 column. This column can be successfully operated with the addition of 15% IPA.
Nov 08, 2017
Sponsored Content - NA
The TSKgel UP-SW3000 column is ideally suited for the analysis of aggregate and fragment contents of antibody preparations. It features the same pore size as the TSKgel G3000SWXL column while improving resolution through smaller particle size.
Nov 08, 2017
Sponsored Content - NA
This Application Note demonstrates the use of a 4.6 mm ID × 15 cm TSKgel SuperSW mAb HTP SEC column for the highly reproducible separation of antibodies in less than 3.5 minutes by using a moderate flow rate of 0.75 mL/min.
Nov 08, 2017
Sponsored Content - NA
This study demonstrates the effectiveness of the TSKgel UltraSW Aggregate, 3 μm SEC column for monitoring protein unfolding and refolding in protein stability studies.
Nov 08, 2017
Sponsored Content - NA
Coupling analysis by size exclusion chromatography/mass spectrometry (SEC/MS) using a TSKgel®SuperSW3000 column and hydrophobic interaction chromatography (HIC) using a TSKgel Butyl-NPR column allowed elucidation and verification of the drug-to-antibody ratio (DAR) profile of an ADC mimic.
Nov 06, 2017
Sponsored Content
The below Clean Screen® XCEL I method can be utilized for both universal screening and confirmatory purposes when extracting various drugs from oral fluid prior to analysis by LC-MS/MS. By evaporating to completion, final extracts are purified and highly concentrated to achieve required levels of detection/quantitation.
Oct 26, 2017
Sponsored Content - EU
Here, we demonstrate screening and quantitation for 246 pesticides and metabolites using an Agilent Ultivo Triple Quadrupole LC–MS.
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