LCGC Blog

May 09, 2018
It’s excellent to see that compendial authorities are considering updating “allowable change” regulations, and the updates to allow changes to gradient profiles certainly open up a whole new world, but there are some reservations around the new restrictions on allowable changes to stationary-phase chemistry.
May 03, 2018
One of the initiatives that the SCSC oversees is the nomination process and awarding of the Satinder Ahuja Award for Young Investigators in Separation Science. Where are all of the young investigators in separation science? Certainly, those that have been honored to date have been worthy; however, there must be more eligible parties out there.
Apr 09, 2018
What is the chemistry of this phase? What are the mechanisms of interaction with the analyte and hence how is retention and selectivity gained from this phase? How can we troubleshoot separation problems or develop suitable methods without a good knowledge of the bonded-phase chemistry?
Apr 03, 2018
I do not remember the application, but I remember very clearly Professor McNair telling us that soil is one of the most challenging sample matrices, if not the toughest, from which to perform analytical determinations. Sources indicate the composition of soil ideal for growing plants to be 25% air, 25% water, 45% minerals, and 5% organic matter. That does not seem like a daunting makeup, but the reality is that the relative proportion of the constituents can vary dramatically.
Mar 09, 2018
The overriding majority of articles on problems with the technical transfer of HPLC methods ultimately focus on differences between HPLC dwell volumes. However, as the title suggests, there are many more issues which can cause problems in the transfer of HPLC methods, and I wanted to highlight some common issues that come across my desk, in the hope that it will help you avoid these problems in your own practice.
Mar 06, 2018
Several years ago, I would have held the stance that environmental analysis was fairly boring. How complicated can water be? I am not ashamed to say that was a naïve view. It is clear from our research and related research by others on similar topics that much more work in these areas is needed. Standard methods cannot solely accommodate the growing list of targets and the multitude of unknowns associated with complex samples taken from the interface between the petroleum industry and the environment.
Feb 06, 2018
I'm often asked to help with the development of column "screening" platforms and automated development systems. While this covers a large amount of analytical science there are some common elements to this type of approach, perhaps the most important of which is column selection. Unsurprising given that "selectivity" is the most powerful tool we have in chromatography and we all know that the best way to optimize selectivity is to choose the most appropriate stationary phase.
Jan 30, 2018
I always think of a conference presentation to be like a rock band concert. Sure, the band is going to play some of their biggest hits, but they also want to propagate their new stuff. More importantly, they want to put on a show so that people are entertained. I do think there should be more emphasis on entertaining the audience during oral presentations.
Jan 09, 2018
Sometimes troubleshooting a separation can rely upon the end user spotting subtle clues within the chromatogram, and at other times the visual signs can be much more obvious. To start the New Year, I wanted to share some of the most common issues that we see with peak shapes in gas chromatography in the hope that if you spot some of these in your own work, you may be able to intercept problems and deal with them more effectively.
Jan 03, 2018
E-Separation Solutions
Two things were surprising about some recent research we reported. First, with regard to chemically impaired groundwater quality, it may not always be the chemicals that are most worrisome for human health impacts. Second, the primary methodology we used in that work for microorganism identification, matrix-assisted laser desorption–ionization mass spectrometry (MALDI-MS), is a vastly underappreciated tool, especially outside the clinical realm in areas such as environmental monitoring.
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