LCGC Blog

Nov 15, 2016
As we enter the Generalization phase of the industrialization of Analytical Science, we find ourselves striving for the generic in as many areas as possible.
Nov 08, 2016
As I wrote the title of this month’s installment, I could not help but wonder where the cliché “more than one way to skin a cat” came from. Turns out it is from Mark Twain in his 1889 work, A Connecticut Yankee in King Arthur’s Court. I have never read that book, but I certainly have heard this saying used more than once—even if it might offend some cat lovers. Of course, it means simply that there is more than one way to do something.
Nov 07, 2016
The Column
Kevin A. Schug reveals the major method validation protocol deficiencies he discovered when he reviewed a blood alcohol investigation and discusses how matrix effects possibly resulted in blood alcohol concentrations being over-estimated, resulting in a potentially significant injustice.
Oct 18, 2016
The LCGC Blog
I started my career working in a Quality Control laboratory. I'm familiar with the constraints that must be imposed to ensure consistent global standards and the pace at which change can be implemented without loss of control either within a business or across an industry. OK—scene set.
Oct 11, 2016
The LCGC Blog
I am quite excited about some recent work we and others have performed related to fuels analysis using gas chromatography and vacuum ultraviolet spectroscopy (GC–VUV).
Sep 13, 2016
I’ve often written about the “lazy” chromatography which has swept through our industry, whereby 0.1% (w/w or w/v!) TFA or formic acid is used to “buffer” the eluent system well away from the pKa of analyte molecules, leaving most acidic analytes in the ion suppressed form and most basic analytes in the ionized form. This approach avoids having issues with retention time drift and effectively eliminates pH as a variable used to control retention or selectivity for separations involving ionogenic analytes.
Sep 09, 2016
The Column
Kevin A. Schug discusses how matrix-assisted laser desorption–ionization time-of-flight mass spectrometry (MALDI-TOF-MS) is one of the most versatile tools for fingerprinting mixtures.
Sep 07, 2016
The LCGC Blog
In a recent review of blood alcohol casework performed by a forensics laboratory associated with a major metropolitan police force, I was again disheartened to find major deficiencies in method validation protocols. In this case, the analysts failed to check whether aqueous solutions for calibration and quality control were reliable surrogates for real blood samples.
Aug 16, 2016
I’ve done that thing where I’ve stated a very interesting title—I hope I can deliver something which lives up to it. I dislike it when people “overstate” their talk or poster titles at conferences to draw me in and then don’t deliver against the promise—I’ll let you judge how we go here.
Aug 09, 2016
Top-down protein quantitation, especially using triple-quadrupole MS, but even in general, has hardly been pursued. To help fill this gap, we recently reported a systematic investigation of intact-protein quantitation using multiple reaction monitoring (MRM) on a triple-quadrupole MS system, and we believe that this approach can be a promising alternative route to consider going forward.
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