LCGC Blog

Jul 12, 2016
The LCGC Blog
Matrix-assisted laser desorption–ionization time-of-flight mass spectrometry (MALDI-TOF-MS) is actually one of the most versatile tools for fingerprinting mixtures.
Jun 14, 2016
I believe that most analytical chemists do not appreciate what the world of chemometrics and experimental design statistics can add to their work.
Jun 07, 2016
Not every method is as we would hope it would be. Some methods come to us in imperfect form and we have to live with them, while others are difficult separations and, by necessity, need to be developed using close control of several variables such as eluent pH, eluotropic strength, ionic strength, and so on.
May 17, 2016
In 2009 I wrote an article on the emerging field “Bio Chromatography,” which for a small molecule analyst such as myself, perfectly described the situation. I realize that the separation of biomolecules had been happening for many years, but the expansion and development of protein based therapeutics from that point onwards has seen an avalanche of developments in instrumentation, sample preparation, and column technologies the like of which I have not seen in my 30 year career.
May 11, 2016
Compared to the magnitude of unconventional oil and gas development activity that has been performed by industry, the amount of research to assess its potential environmental impact has been miniscule. Can the process have a deleterious impact if not well managed? Can it be performed in a responsible manner?
Apr 11, 2016
I often get asked about the other important aspects of “screening” in HPLC, which include the mobile phase composition, gradient parameters and flow rate – so that’s the theme of this installment.
Apr 08, 2016
Here, I will attempt to convey a few basic but critical concepts when getting started in the development of a new LCxLC method.
Mar 15, 2016
LCGC North America
I’ve been talking about ‘ToolKit’ method development platforms a lot lately and I have to say I’m not sure we are making the most of this approach.
Mar 09, 2016
The Column
What is required to produce a highly efficient modern high performance liquid chromatography (HPLC) system/column combination? This instalment of the LCGC Blog explains more.
Mar 08, 2016
The literature on reversed-phase liquid chromatography of proteins is reasonably well developed, but not taught in the college classroom much. I would like to focus on a stoichiometric displacement model for reversed-phase LC of proteins and why it is particularly insightful from a practical perspective.
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