Brent Murphy

Separation Science in Drug Development, Part 1: High-Throughput Purification

LCGC Europe - Jun 01, 2015

This instalment provides an overview of modern practices of high-throughput purification to support small-molecule drug discovery. It describes the use of reversed-phase liquid chromatography (LC) and supercritical fluid chromatography (SFC) for purifying diverse samples in a centralized laboratory setting. A case study is used to illustrate the principles and rationales for selecting operating parameters for these applications. This is the first instalment of four articles on “Separation Science in Drug Development” to describe the modern practice of separation science in supporting small-molecule drug discovery and development.

Separation Science in Drug Development, Part I: High-Throughput Purification

LCGC North America - Jun 01, 2015

This installment provides an overview of modern practices of high-throughput purification to support small-molecule drug discovery.

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