Column: Perspectives in Modern HPLC

Aug 01, 2015
LCGC North America
This installment provides an overview of high-throughput characterization techniques of drug leads to support small molecule drug discovery programs in a pharmaceutical company. A myriad of analytical chemistry techniques including separation science methodologies are used to confirm the structures and identities, quantitating the concentrations of stock solutions, and measuring key physicochemical properties of the new chemical entities (NCE). A case study is used here to illustrate the details of these applications in high-throughput characterization.
Jun 01, 2015
LCGC North America
This installment provides an overview of modern practices of high-throughput purification to support small-molecule drug discovery.
Apr 01, 2015
LCGC North America
This installment highlights noteworthy high performance liquid chromatography (HPLC) and related products introduced at Pittcon 2015 in New Orleans, Louisiana, as well as in the year prior.
Oct 01, 2014
LCGC North America
The latest approaches to antibody characterization go beyond ion-exchange, size-exclusion, and reversed-phase modes to make use of affinity, hydrophobic interaction, mixed-mode, and HILIC techniques.
Aug 01, 2014
LCGC North America
Because of improved technologies and other changes in modern HPLC, these seven common practices are now highly questionable.
Jun 01, 2014
LCGC North America
An updated overview of the development of SPP technology, including benefits, limitations, and the theory behind its success
Apr 01, 2014
LCGC North America
Noteworthy new HPLC systems and related products
Oct 01, 2013
LCGC North America
A number of popular myths or half-truths in UHPLC are described and data are provided that contradict some of these commonly held beliefs.
Aug 01, 2013
LCGC North America
HPLC method development can be accelerated by using three distinct method templates of increasing complexity.
Jun 01, 2013
LCGC North America
The fundamental concepts of HPLC are re-examined.
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