LC Troubleshooting

Mar 01, 2018
LCGC North America
Certain details related to mobile-phase preparation that can be assumed in reversed-phase LC separations can be much more consequential in HILIC.
Feb 01, 2018
LCGC North America
In advance of Pittcon 2018, leading scientist John Dolan, who will be speaking at the LCGC awards symposium, gives us a preview of his talk.
Jan 01, 2018
LCGC North America
Paying attention to the details of mobile-phase preparation can have a big impact on the reproducibility of HILIC separations.
Dec 01, 2017
LCGC North America
What are the most useful chromatography books on your bookshelf? What are the most useful web-based resources (such as websites, downloadable documents, videos) about separation science? What are the most useful tools supporting your work (such as calculators and simulators)? In this installment, Dwight Stoll compiles input from the separation science community (both individuals and vendors) to guide you to the resources that people find most useful.
Nov 01, 2017
LCGC North America
What’s not in your standard operating procedure? Documenting details can prevent headaches associated with method transfers between laboratories.
Oct 01, 2017
LCGC North America
In his final column before retirement, John Dolan reflects on the changes he has seen during his 34 years as the author of “LC Troubleshooting,” and shares his short list of best practices that still hold true today.
Sep 01, 2017
LCGC North America
When developing or modifying an LC separation, a common strategy is to change selectivity by choosing a new column. Here’s guidance for making that selection.
Aug 01, 2017
LCGC North America
You have to be careful when adjusting gradient conditions.
Jul 01, 2017
LCGC North America
We consider some of the details associated with preparing a column for storage, with an eye toward choices that will pay dividends in future use.
Jun 01, 2017
LCGC North America
How much of a change can you make to a USP method without revalidating the method?
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