The LCGC Blog

May 07, 2013
E-Separation Solutions
By LCGC Editors
Kevin Schug discusses the power of MS for resolving an enormous number of compounds in a sample.
Apr 16, 2013
The LCGC Blog
By LCGC Editors
The physical characteristics of silica-based HPLC columns can affect the performance of the separation almost as much as the bonded phase. This month's technical tip re-visits some of the lesser known or remembered facts relating to silica particles used for chromatography.
Apr 09, 2013
The LCGC Blog
By LCGC Editors
Oceanographers have extremely challenging analysis problems to overcome. Can analytical chemists help? The Collaborative on Oceanographic Chemical Analysis workshop, sponsored by the National Science Foundation, connects scientists in these two fields to exchange ideas. And that is good, because the needs are great. Kevin Schug takes a look at where that collaboration might lead.
Mar 26, 2013
The LCGC Blog
By LCGC Editors
A number of retention time issues can cause problems in HPLC. Here's advice on how to handle common ones, such as retention time drift, temperature variability, problems arising from column equilibration, and difficulties validating a method.
Mar 13, 2013
The LCGC Blog
By LCGC Editors
Method validation is a concept that has been ingrained (or should have been ingrained) in the minds of most analytical chemists. Any new method that is created has to be proven reliable and provide some level of performance under well-defined conditions.
Feb 19, 2013
The LCGC Blog
By LCGC Editors
Should HPLC eluent additives be added to one or both of the constituent mobile phase reservoirs - both organic and aqueous, when mixing gradients online?
Feb 06, 2013
The LCGC Blog
By LCGC Editors
Derivatization of the analytes targeted in an HPLC-ESI-MS separation can help improve detection limits.
Jan 18, 2013
The LCGC Blog
By LCGC Editors
In this months technical tip we answer some often asked questions and dispel some myths regarding HPLC column abuse and reconditioning
Jan 07, 2013
The LCGC Blog
By LCGC Editors
Restricted-access media (RAM) offer many advantages and can make it easier to achieve efficient and reproducible on-line sample preparation. In spite of this, these media have been underutilized. It is time for more research into RAM.
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