The LCGC Blog

Apr 11, 2016
I often get asked about the other important aspects of “screening” in HPLC, which include the mobile phase composition, gradient parameters and flow rate – so that’s the theme of this installment.
Apr 08, 2016
Here, I will attempt to convey a few basic but critical concepts when getting started in the development of a new LCxLC method.
Mar 15, 2016
LCGC North America
I’ve been talking about ‘ToolKit’ method development platforms a lot lately and I have to say I’m not sure we are making the most of this approach.
Mar 08, 2016
The literature on reversed-phase liquid chromatography of proteins is reasonably well developed, but not taught in the college classroom much. I would like to focus on a stoichiometric displacement model for reversed-phase LC of proteins and why it is particularly insightful from a practical perspective.
Feb 16, 2016
If you don’t examine your LC–MS data closely, you could be missing some of these effects, and those problems with your quantitative data will never be fixed.
Feb 09, 2016
The LCGC Blog
Food analysis provides a rich sample matrix with many compounds of interest for analysis to contemplate—but one must always take care that the right tool is chosen for the desired task.
Jan 20, 2016
Some modern HPLC systems resemble spacecraft in terms of their technology, designed as they are to operate to the highest efficiencies, compared to traditional systems. However, I still see countless examples where high efficiency columns are used on systems which are not matched and cannot support the highest efficiencies offered by the column.
Jan 13, 2016
After 10 years at U.T. Arlington, I have decided it is time to take one of the best opportunities afforded to researchers in an academic faculty position—to travel abroad and assimilate new techniques into my repertoire to enhance future research activities.
Dec 14, 2015
There has been much written about the use of nitrogen as a carrier gas for capillary GC. Formerly, to say it wasn’t any good. Latterly to say that it’s pretty good and a better alternative to Helium than hydrogen from a practicality standpoint.
Dec 09, 2015
E-Separation Solutions
It is much more efficient to screen column chemistries to achieve optimum separations for a set of target analytes, than it is to play with different mobile-phase conditions on a single column. Kevin Schug explains more.
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