The LCGC Blog

Feb 16, 2016
If you don’t examine your LC–MS data closely, you could be missing some of these effects, and those problems with your quantitative data will never be fixed.
Feb 09, 2016
The LCGC Blog
Food analysis provides a rich sample matrix with many compounds of interest for analysis to contemplate—but one must always take care that the right tool is chosen for the desired task.
Jan 20, 2016
Some modern HPLC systems resemble spacecraft in terms of their technology, designed as they are to operate to the highest efficiencies, compared to traditional systems. However, I still see countless examples where high efficiency columns are used on systems which are not matched and cannot support the highest efficiencies offered by the column.
Jan 13, 2016
After 10 years at U.T. Arlington, I have decided it is time to take one of the best opportunities afforded to researchers in an academic faculty position—to travel abroad and assimilate new techniques into my repertoire to enhance future research activities.
Dec 14, 2015
There has been much written about the use of nitrogen as a carrier gas for capillary GC. Formerly, to say it wasn’t any good. Latterly to say that it’s pretty good and a better alternative to Helium than hydrogen from a practicality standpoint.
Dec 09, 2015
E-Separation Solutions
It is much more efficient to screen column chemistries to achieve optimum separations for a set of target analytes, than it is to play with different mobile-phase conditions on a single column. Kevin Schug explains more.
Nov 17, 2015
They say a picture paints a thousand words… This month I’ve taken inspiration from a recent webcast, presented at, in which I presented real data from our work that represents some ‘classic’ GC problems.
Nov 10, 2015
Column overload is a very commonly encountered issue in GC for beginners. Changes in peak symmetry, generally observed as peak fronting, can be subtle in the sharp peaks generated by GC, but the result can be significant shifts in retention times, loss of resolution, and error in peak integration.
Oct 12, 2015
A client asked me recently for a quick but "as optimized as possible" separation for some monoclonal antibody (MAb) characterization (digest) samples using LC-MS. The samples had been prepared and were awaiting analysis—typical forward planning! Actually his internal analytical department had changed their priority and he was left hanging.
Oct 07, 2015
If you want to improve analytical methods to make them better, the sample preparation step is probably one of the best steps to target.
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