LCGC North America January 2015

January 2015 | Volume 33, Issue 1
MS – The Practical Art
The use of a mass spectrometer in quantitative analysis exploits its exquisite selectivity and sensitivity as a detector, allowing a signal to be ascribed to a particular chemical entity with high certainty, even when present in a sample at a low concentration.
LC Troubleshooting
Have a problem with your LC system? Maybe applying a little "DDT (Don't Do That)" may help.
Sample Prep Perspectives
When pyrolyzed, macromolecules will decompose into smaller fragments that can have the appropriate volatility for gas chromatography (GC) separation and analysis.
GC Connections
Some might consider gas chromatography (GC) a mature technique. However, several substantial advances in GC technology in the past few years have proven that there is still room for innovation.
Biotechnology Today
Most analytical approaches used for the determination of low-molecular-weight noncovalent aggregates in protein pharmaceuticals suffer from important limitations. This first part of this two-part column series discusses those limitations.
The Essentials
The ideal UV detector would allow us to monitor the presence of our target analytes without influence from the background eluent and sample matrix components that may be present in the detector measuring cell at the same time
Featured Article
On October 21, 2014, University of Tennessee Distinguished Scientist Georges Andre Guiochon succumbed to neuromuscular failure caused by post-polio syndrome. Here, we pay tribute to his remarkable career and life.
Peer-Reviewed Article
Environmental sample analysis by large-volume injection (LVI) in combination with liquid chromatography–tandem mass spectrometry (LC–MS-MS) is described for polar and nonpolar analytes in both aqueous samples and organic extracts.
From the Editor
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