LCGC North America August 2014

August 2014 | Volume 32, Issue 8
Perspectives in Modern HPLC
Because of improved technologies and other changes in modern HPLC, these seven common practices are now highly questionable.
Column Watch
Mechanical strength, acid and alkaline durability, loadability, and overload characteristics are a few of the parameters evaluated.
LC Troubleshooting
Small changes in retention time with an LC method are normal. At what point is a problem suggested?
Peer-Reviewed Articles
Recent developments have made organic polymer monoliths much more suitable for the separation of small molecules.
When transferring a method between HPLC and UHPLC, various potential pitfalls may result in selectivity differences, changes in efficiency, and failure to meet resolution system suitability criteria.
What are the characteristics and relevant considerations for the development and validation of a stability-indicating method?
The Essentials
An overview of the analytical approaches used for the analysis of biomolecules
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