LCGC North America August 2015

August 2015 | Volume 33, Issue 8
LCGC North America August 2015 issue
Sample Prep Perspectives
Recently, Nature and Science Citation Index listed the 100 most cited research papers of all time. Two of these are the classic Bligh-Dyer and Folch lipid extraction methods from the late 1950s. This month we will take a look at the lasting impact of these papers and explore the current state of lipid extractions, including lipidomics.
LC Troubleshooting
How to distinguish between LC column overload and detector overload.
Perspectives in Modern HPLC
This installment provides an overview of high-throughput characterization techniques of drug leads to support small molecule drug discovery programs in a pharmaceutical company. A myriad of analytical chemistry techniques including separation science methodologies are used to confirm the structures and identities, quantitating the concentrations of stock solutions, and measuring key physicochemical properties of the new chemical entities (NCE). A case study is used here to illustrate the details of these applications in high-throughput characterization.
History of Chromatography
Professor Wolfgang Lindner spoke to LCGC Editorial Advisory Board member Kevin A. Schug about his inspiring and influential career in chromatography.
The Essentials
Gain an invaluable insight into the key methods that are used for biomolecule characterization, process control, and release testing
Peer-Reviewed Article
Before we can define an ideal CDS, we must first consider its role.
Guest Editorial
What exactly is SFC? Although you may have heard and read much about it recently, it is still rather vague to many a chromatographer.
In Memoriam
A memoir of Phyllis Brown—a pioneering chromatographer, a devoted mentor, and a champion for women in science
Chromatography Corner
By LCGC Editors
Mélisande Bernard is developing chromatographic methods to detect substandard cardiovascular drugs in Africa.
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