LCGC North America October 2004

October 2004 | Volume 22, Issue 10
Sample Prep Perspectives
This month'ss guest authors review the application of solid-phase SPME to the analysis of drugs in human plasma.
LC Troubleshooting
By LCGC Editors
Just how good are your gradients?
GC Connections
This month's "GC Connections" examines the various ways – and their attendant benefits and drawbacks – with which chromatographers and chromatography data-handling systems locate and measure peaks
Directions in Discovery
By LCGC Editors
This month'ss "Directions in Discovery" column discusses current work in the use of capillary isoelectric focusing and mass spectrometry as a multidimensional separation technique for proteomic studies.
The authors describe a sensible approach for validation and implementation of HPLC IPC assays.
The use of a silica column for HILIC is examined, including mechanistic studies of analyte retention on silica in aqueous-organic mobile phases.
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