http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Article/list/38978 Peer-reviewed research on HPLC - high performance liquid chromatography. Analytical chemistry info for separation scientists & chromatographers - from LCGC. 2013-05-25T14:27:06Z http://www.chromatographyonline.com/lcgc/Articles/Speciation-Analysis-of-Mercury-in-Sediments-by-HPL/ArticleStandard/Article/detail/812774?contextCategoryId=38978&ref=25 A novel method for analysing mercury in sediment is described. The technique involves microwave-assisted extraction followed by high performance liquid chromatography (HPLC) hyphenated to vapour generation atomic fluorescence spectrometry (VGAFS). 2013-05-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/192013/812774null XML http://www.chromatographyonline.com/lcgc/Articles/HPLC-Systems-and-Modules-Introduced-at-Pittcon-201/ArticleStandard/Article/detail/810668?contextCategoryId=38978&ref=25 The first instalment of the Perspectives in Modern HPLC column highlights some of the new HPLC systems, accessories and related technology introduced at Pittcon this year. 2013-04-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/162013/810668/PerspectivesThumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/162013/810668/PerspectivesFlash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Article/Detection-and-Identification-of-Natural-Antioxidan/ArticleStandard/Article/detail/807706?contextCategoryId=38978&ref=25 Multiple fractions can be tested in parallel with this fast method. 2013-03-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/102013/807706null XML http://www.chromatographyonline.com/lcgc/Articles/Column-Selection-for-Reversed-Phase-HPLC/ArticleStandard/Article/detail/807410?contextCategoryId=38978&ref=25 There are many factors that influence the performance of a high performance liquid chromatography (HPLC) stationary phase, of which the chemical nature of the bonded phase ligand is important, but by no means all encompassing. Minor manufacturing parameters such as the method of electropolishing the internal surface of the column can also have an effect on the selectivity and efficiency produced by a particular column. 2013-03-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/102013/807410/EssentialsThumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/102013/807410/EssentialsFlash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Article/Landmarks-in-the-Evolution-of-Ion-Chromatography/ArticleStandard/Article/detail/810197?contextCategoryId=38978&ref=25 From the invention of eluent suppression to today's "just add water" concept, pivotal developments over the last 40 years are chronologically highlighted from a chemical and instrumental viewpoint. 2013-04-02T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/152013/810197/LCGCNASupp0413Thumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/152013/810197/LCGCNAICSuppFlash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Articles/We-Just-Cant-Do-It/ArticleStandard/Article/detail/805427?contextCategoryId=38978&ref=25 Incognito found a 2D LC solution to a tricky separation problem but this technique did not meet the client's requirements. The magnanimous columnist admits to a rare defeat on this occasion but praises the thrill of seeking a solution to a perplexing method development problem. Could any readers suggest a more straightforward solution? 2013-02-18T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/072013/805427/IncognitoThumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/072013/805427/IncognitoFlash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/Current+Articles/Analysis-of-the-State-of-the-Art-Liquid-Chromatogr/ArticleStandard/Article/detail/784872?contextCategoryId=38978&ref=25 In honor of LCGC's celebration of 30 years covering the latest developments in separation science, we asked a panel of experts (listed in the sidebar) to assess the current state of the art of liquid chromatography (LC) column technology, and to try to predict how the technology will develop in the future. This article is part of a special group of articles covering the state of the art in sample preparation, gas chromatography (GC) columns, GC instrumentation, LC columns, and LC instrumentation. 2012-08-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/322012/784872/LCGCNorthAmerica_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/322012/784872/nopicnaflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Pharmaceutical/Strategies-for-Rapid-Chiral-HPLC-Method-Developmen/ArticleStandard/Article/detail/770407?contextCategoryId=38978&ref=25 Automated column and mobile phase screening is the current trend in the pharmaceutical industry to develop chiral methods. This study presents comprehensive strategies for automated rapid chiral HPLC method development including normal-phase, reversed-phase and polar organic phase separation modes. 2012-04-19T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/172012/770407/ZhangThumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/172012/770407/ZhangFlash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/Article/A-New-Generation-of-Silica-Based-Monoliths-HPLC-Co/ArticleStandard/Article/detail/772076?contextCategoryId=38978&ref=25 Monolithic columns feature both high column efficiency and high column permeability. This article discusses their preparation, applications, and future prospects. 2012-04-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/182012/772076null XML http://www.chromatographyonline.com/lcgc/Article/Advancements-in-the-Understanding-of-Stationary-Ph/ArticleStandard/Article/detail/772071?contextCategoryId=38978&ref=25 Some of the newer hydrophilic interaction liquid chromatography (HILIC) columns are reviewed, and experiments performed to categorize columns for optimized separations are described. 2012-04-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/182012/772071null XML http://www.chromatographyonline.com/lcgc/Articles/Determination-of-Phenylurea-Herbicides-in-Tap-Wate/ArticleStandard/Article/detail/762328?contextCategoryId=38978&ref=25 A simple and sensitive high performance liquid chromatography (HPLC) method with ultraviolet (UV) detection was developed to analyse phenylurea herbicides: – monuron, diuron, linuron, metazachlor and metoxuron – in three soft drink brands and tap water. 2012-03-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/092012/762328/tapwaterthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/092012/762328/tapwaterflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Articles/Using-MS-Data-for-Peak-Tracking-in-Computer-Suppor/ArticleStandard/Article/detail/757842?contextCategoryId=38978&ref=25 A systematic way to develop HPLC methods consists of building up and running a useful set of experiments (DOE, design of experiments) to evaluate the influence of several factors or method conditions on the selectivity of a chromatogram. The crucial part here is the peak tracking between the chromatograms. 2012-02-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062012/757842/MolnarThumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062012/757842/MolnarFlash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/LC/A-Case-of-Sporadic-LC-Assay-Results/ArticleStandard/Article/detail/756794?contextCategoryId=38978&ref=25 A mysterious autosampler problem is solved. 2012-02-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/042012/756794/lctroublethumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/042012/756794/lctroubleflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Articles/Current-Trends-in-HPLC-Column-Technology/ArticleStandard/Article/detail/756695?contextCategoryId=38978&ref=25 The results of a recent survey on high performance liquid chromatography (HPLC) columns shows some interesting changes. 2012-01-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/032012/756695/CW_icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/032012/756695/CW_icon_MAIN_main.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/032012/756695/CW_icon_FLASH_flash.jpg XML http://www.chromatographyonline.com/lcgc/Column%3A+Sample+Prep+Perspectives/Hollow-Fiber-Liquid-Phase-Microextraction-in-the-T/ArticleStandard/Article/detail/752500?contextCategoryId=38978&ref=25 The practical aspects of hollow-fiber liquid-phase microextraction in the three-phase mode (HF3LPME) are described. 2011-12-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/512011/752500/SPPflash_main.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/512011/752500/SPPflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Highlights-of-HPLC-2011/ArticleStandard/Article/detail/736770?contextCategoryId=38978&ref=25 A review of HPLC 2011, which took place in Budapest, Hungary in June this year. 2011-09-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/352011/736770/CWthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/352011/736770/CWflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Articles/GPCSEC-Columns---Dos-and-Donts/ArticleStandard/Article/detail/733872?contextCategoryId=38978&ref=25 The GPC/SEC column is the key component for the separation of macromolecules by size. It enables a conventional HPLC instrument to be used for GPC/SEC analysis. 2011-07-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/322011/733872/holethumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/322011/733872/holeflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/Articles/Market-Profile-Flash-Chromatography/ArticleStandard/Article/detail/731238?contextCategoryId=38978&ref=25 Flash chromatography is a type of preparative liquid chromatography commonly used in the separation of organic compounds. 2011-06-17T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/292011/731238null HTML http://www.chromatographyonline.com/lcgc/Industry%3A+Biological/Sports-doping-detection-award/ArticleStandard/Article/detail/729383?contextCategoryId=38978&ref=25 The 2011 Manfred Donike award for scientific excellence in sports-doping testing has been presented to Simon Beuck and Nicolas Leuenberger. 2011-06-09T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/272011/729383null HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Innovation-programme/ArticleStandard/Article/detail/729381?contextCategoryId=38978&ref=25 Waters has welcomed the Proteomics Core Facility at the Duke University School of Medicine, Durham, North Carolina, USA, into its Centers of Innovation programme. 2011-06-07T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/272011/729381null HTML http://www.chromatographyonline.com/lcgc/Industry%3A+Polymer/Comprehensive-Two-dimensional-Liquid-Chromatograph/ArticleStandard/Article/detail/731549?contextCategoryId=38978&ref=25 In this review, practical principles and guidelines for designing LC?LC methods are given. 2011-06-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/292011/731549null XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/My-First-Motor-Car/ArticleStandard/Article/detail/724656?contextCategoryId=38978&ref=25 Incognito draws similarities between advances in car technology and HPLC systems. Better end products have come at the cost of knowledge about how it actually works and can be maintained. 2011-05-18T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/222011/724656/incogthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/222011/724656/incogflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Looking-for-biomarkers/ArticleStandard/Article/detail/723521?contextCategoryId=38978&ref=25 The Singapore Eye Research Institute will advance biomarker candidates that it has identified for chronic inflammatory eye conditions into large-scale clinical trials for validation using AB SCIEX technology. 2011-05-17T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/212011/723521null HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Ultrapure-Water-for-Nano-LC-MS/ArticleStandard/Article/detail/723516?contextCategoryId=38978&ref=25 This work presents a proof of concept that using freshly produced ultrapure water to prepare nano LC eluent does not cause emitter clogging. 2011-05-09T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/212011/723516/tarunthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/212011/723516/tarunflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/Column%3A+Innovations+in+HPLC/HPLC-Systems-and-Components-at-Pittcon/ArticleStandard/Article/detail/725245?contextCategoryId=38978&ref=25 This year, many HPLC systems focused on facilitating process development, method transfer, and biological analysis. 2011-05-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/232011/725245/Innovat_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/232011/725245/Innovat_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/LC/Establishing-Reference-Standards/ArticleStandard/Article/detail/725252?contextCategoryId=38978&ref=25 Here's how these new reference standards were characterized. 2011-05-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/232011/725252/dangthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/232011/725252/dangflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Articles/Achiral-SFC-Purification-of-Pharmaceuticals/ArticleStandard/Article/detail/725247?contextCategoryId=38978&ref=25 This process can improve efficiency in a drug discovery laboratory. 2011-05-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/232011/725247/Lazarescuthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/232011/725247/Lazarescuflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Industry%3A+Polymer/Comprehensive-2D-LC-A-Review/ArticleStandard/Article/detail/726701?contextCategoryId=38978&ref=25 In this review, practical principles and guidelines for designing LCxLC methods are given. 2011-05-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/242011/726701/hyotylainenthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/242011/726701/hyotylainenflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Column%3A+LC+Troubleshooting/Ghost-Peak-Investigation-in-a-Reversed-Phase-Gradi/ArticleStandard/Article/detail/725248?contextCategoryId=38978&ref=25 Here is a step-by-step approach to investigate the source of ghost peaks in a gradient LC method. 2011-05-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/232011/725248/LCTrub_Icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/232011/725248/LCTrub_Icon_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Industry%3A+Chiral/Chiral-Stationary-Phase-Development/ArticleStandard/Article/detail/726698?contextCategoryId=38978&ref=25 The development of chiral column technology since the review in 2008 is discussed by Thomas Beesley. 2011-05-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/242011/726698/CWthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/242011/726698/CWflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Industry%3A+Biological/Turnkey-MS-methods/ArticleStandard/Article/detail/722376?contextCategoryId=38978&ref=25 The Canadian National Research Council?s Institute for Marine Biosciences (NRC-IMB) has signed an agreement with AB SCIEX that will enable researchers worldwide to benefit from the insitute?s experience in the detection and identification of marine and freshwater biotoxins and the creation of certified reference materials. 2011-04-26T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/202011/722376null HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Spark-of-life/ArticleStandard/Article/detail/722375?contextCategoryId=38978&ref=25 In 1958 the University of Chicago zapped a simulated primordial earth atmosphere with a series of electrical discharges to demonstrate the way in which organic compounds may have been originally synthesized on Earth. Archived and unreported samples have recently been uncovered and submitted to modern analytical techniques, which have revealed even more abundant amino acid and amine yields than previous experiments. 2011-04-21T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/202011/722375null HTML http://www.chromatographyonline.com/lcgc/Current+Articles/Is-Chromatography-Boring/ArticleStandard/Article/detail/722370?contextCategoryId=38978&ref=25 What fuels our enthusiasm and transforms what on first appearance may seem a boring technique into something that offers inspiration? 2011-04-18T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/202011/722370/incogthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/202011/722370/incogflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/Column%3A+LC+Troubleshooting/Selectivity-in-RP-LC-Part-4-Pressure-Selectivity/ArticleStandard/Article/detail/719056?contextCategoryId=38978&ref=25 Can pressure alone affect the appearance of a chromatogram? 2011-04-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/192011/719056/LCTrub_Icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/192011/719056/LCTrub_Icon_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Articles/Determination-of-Phenylurea-Herbicides/ArticleStandard/Article/detail/719057?contextCategoryId=38978&ref=25 A high performance liquid chromatography (HPLC)–UV method was developed for the analysis of phenylurea herbicides and applied successfully to the analysis of herbicides spiked in three soft drink brands and tap water. 2011-04-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/192011/719057/kaurthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/192011/719057/kaurflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/The-Chromatography-of-Sunshine/ArticleStandard/Article/detail/716916?contextCategoryId=38978&ref=25 The ability to determine vitamin D levels in patients rapidly and reliably is a valuable tool in identification and management of treatment regimes. 2011-04-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/172011/716916null HTML http://www.chromatographyonline.com/lcgc/Column%3A+The+History+of+Chromatography/My-Mentors-Colleagues-and-Friends-in-Separation-Sc/ArticleStandard/Article/detail/719060?contextCategoryId=38978&ref=25 Often, what you remember most about your career is the great people you met along the way. 2011-04-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/192011/719060/HistoryChrom_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/192011/719060/HistoryChrom_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Articles/HPTLC-Determination-of-Aflatoxin-Bsub1sub/ArticleStandard/Article/detail/719058?contextCategoryId=38978&ref=25 A high performance thin-layer chromatographic (HPTLC) method was developed for the determination of aflatoxin B1 in cereals. 2011-04-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/192011/719058/gaothumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/192011/719058/gaoflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/UHPLC-or-HPLC-The-Choice-is-Yours/ArticleStandard/Article/detail/716920?contextCategoryId=38978&ref=25 Sergio Guazzotti speaks to Janet Kelsey about the advantages of UHPLC over HPLC and issues to consider when selecting this technique. 2011-04-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/172011/716920null HTML http://www.chromatographyonline.com/lcgc/News/System-and-column-collaboration/ArticleStandard/Article/detail/713660?contextCategoryId=38978&ref=25 Phenomenex and Shimadzu Scientific Instruments today announced a marketing collaboration for LC and GC systems. Through this collaboration, Shimadzu systems and Phenomenex columns will be offered together in the United States. 2011-03-17T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/142011/713660null HTML http://www.chromatographyonline.com/lcgc/Column%3A+Column+Watch/New-at-Pittcon-2011/ArticleStandard/Article/detail/714665?contextCategoryId=38978&ref=25 A review of the liquid chromatography columns and accessories for analytical and preparative chromatography to be unveiled at Pittcon 2011 2011-03-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/142011/714665/CW_icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/142011/714665/CW_icon_MAIN_main.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/142011/714665/CWflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/The-Increasing-Role-of-Superficially-Porous-Partic/ArticleStandard/Article/detail/724910?contextCategoryId=38978&ref=25 A review of the development of superficially porous particles and what the latest advances in this technology offer chromatographers in practice. 2011-03-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/222011/724910null XML http://www.chromatographyonline.com/lcgc/Column%3A+LC+Troubleshooting/Selectivity-in-Reversed-Phase-LC-Separations-Part-/ArticleStandard/Article/detail/714660?contextCategoryId=38978&ref=25 Comparisons between different C18 columns and the best way to select which one to use 2011-03-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/142011/714660/LCTrub_Icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/142011/714660/LCTrub_Icon_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Article/HILICndashMS-Sensitivity-without-Silica/ArticleStandard/Article/detail/714661?contextCategoryId=38978&ref=25 What challenges occur when using hydrophilic interaction liquid chromatography (HILIC), and what options are available for analysis? 2011-03-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/142011/714661/pereirathumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/142011/714661/pereiraflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/GC/Food-Metabolomics-Fact-or-Fiction/ArticleStandard/Article/detail/724911?contextCategoryId=38978&ref=25 This article describes important aspects of food metabolomics using tomato paste as an example of this approach in practice. 2011-03-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/222011/724911null XML http://www.chromatographyonline.com/lcgc/Article/The-2011-LCGC-Pittcon-Awards/ArticleStandard/Article/detail/714664?contextCategoryId=38978&ref=25 Now in its fourth year, the LCGC Awards have quickly grown into one of the premier honors for both emerging and veteran practitioners of chromatography. 2011-03-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/142011/714664/Knox_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/142011/714664/Knoxts_flash.jpg XML http://www.chromatographyonline.com/lcgc/Column%3A+History+of+Chromatography/Still-a-Young-Technology-Chiral-Chromatography-Mak/ArticleStandard/Article/detail/712779?contextCategoryId=38978&ref=25 Chiral chromatography is now the fastest way to access large amounts of enantiopure pharmaceutical compounds. 2011-02-11T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/132011/712779/HistoryChrom_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/132011/712779/HistoryChrom_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Column%3A+LC+Troubleshooting/A-Picture-Is-Worth-a-Thousand-Words/ArticleStandard/Article/detail/712778?contextCategoryId=38978&ref=25 A few simple calculations and estimates can provide insight into a troublesome chromatogram. 2011-02-11T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/132011/712778/LCTrub_Icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/132011/712778/LCTrub_Icon_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Articles/Determining-Melamine-in-Milk/ArticleStandard/Article/detail/712777?contextCategoryId=38978&ref=25 High recovery, reproducibility, and cost savings are among the advantages of this environmentally friendly method. 2011-02-11T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/132011/712777/furusawathumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/132011/712777/furusawaflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Industry%3A+Food+and+Beverage/Multi-mycotoxins-in-Beer/ArticleStandard/Article/detail/709164?contextCategoryId=38978&ref=25 The Detection and Quantification of Multi-mycotoxins in Beer Samples using Orbitrap Technology with UHPLC. 2011-02-04T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/092011/709164/godulathumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/092011/709164/godulaflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/News/Its-a-Trapp/ArticleStandard/Article/detail/706344?contextCategoryId=38978&ref=25 To protect the unique trappist brews, a programme funded by the European Commission has attempted to develop methods that would identify the real thing. 2011-02-03T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706344null HTML http://www.chromatographyonline.com/lcgc/GC/Food-Metabolomics-Fact-or-Fiction/ArticleStandard/Article/detail/713025?contextCategoryId=38978&ref=25 It is expected that new developments in analytical chemistry will increase the value of food metabolomics in the future. 2011-02-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/132011/713025/coulierthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/132011/713025/coulierflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/News/Global-biotechnology-instrumentation-market-report/ArticleStandard/Article/detail/704952?contextCategoryId=38978&ref=25 Global Industry Analysts (GIA) has released a global report on the biotechnology instrumentation markets that predicts that it will reach $5.8 billion by the year 2015. 2011-01-31T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/052011/704952null HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Something-to-wine-about/ArticleStandard/Article/detail/706343?contextCategoryId=38978&ref=25 If you are suffering from headaches after a night of wine drinking there is a chance it may be more than the usual hangover. A study published in the Journal of Proteome Research has identified similarities between grape glycoproteins and known plant allergens. 2011-01-25T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706343null HTML http://www.chromatographyonline.com/lcgc/GC/New-Years-Resolutions/ArticleStandard/Article/detail/706334?contextCategoryId=38978&ref=25 Incognito inspires us to improve the way we work by sharing his New Year's resolutions that will make for better working practices. 2011-01-24T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706334/incog1thumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706334/incog1flash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/The-Ins-and-Outs-of-HILIC-Chromatography/ArticleStandard/Article/detail/706336?contextCategoryId=38978&ref=25 Mark Woodruff of Fortis Technologies talks about the background, advantages and applications of hydrophilic interaction chromatography and where its future lies. 2011-01-24T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706336/woodruffthumb2_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706336/woodruffflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Flash-or-HPLC-Is-There-Really-a-Difference/ArticleStandard/Article/detail/706335?contextCategoryId=38978&ref=25 A wide range of instruments, columns and media are available for LC purification, including Flash and HPLC. Are these techniques interchangeable? How do they compare? 2011-01-24T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706335/lloydthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706335/lloydflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/Articles/The-Direct-Analysis-of-Diquat-and-Paraquat-in-Lake/ArticleStandard/Article/detail/706363?contextCategoryId=38978&ref=25 The authors discuss an LC method for the direct analysis of diquat and paraquat in lake water. 2011-01-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706363/robbthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706363/robbflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Column%3A+LC+Troubleshooting/Selectivity-in-Reversed-Phase-LC-Separations-Part-/ArticleStandard/Article/detail/706367?contextCategoryId=38978&ref=25 A change in the mobile phase strength can be a powerful tool to move peaks in a separation. 2011-01-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706367/LCTrub_Icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706367/LCTrub_Icon_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Articles/Toward-a-Universal-Detector-for-Small-Molecule-App/ArticleStandard/Article/detail/706366?contextCategoryId=38978&ref=25 This article describes the operating principles of the direct-electron ionization (EI) interface, which is becoming more popular in many LC–MS applications. Matrix effects and the role of direct-EI as a universal detector for small molecule analysis are also discussed in detail. The advantages and drawbacks of this approach are described and a comparison with atmospheric pressure ionization (API) interfaces is made. The potential of direct-EI is illustrated with a selection of practical applications. 2011-01-01T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/062011/706366null XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Healthy-eating/ArticleStandard/Article/detail/704810?contextCategoryId=38978&ref=25 Whether organic produce provides any actual health benefits is still controversial, and a recent study of organic carrots, onions and potatoes has claimed that the process may add nothing at all. 2010-12-14T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/052011/704810null HTML http://www.chromatographyonline.com/lcgc/News/HPLC-donation/ArticleStandard/Article/detail/704809?contextCategoryId=38978&ref=25 KNAUER has donated a high-quality analyser to the Hamburg University of Technology (TUHH) for use in education and training in the chemical engineering department. 2010-12-09T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/052011/704809null HTML http://www.chromatographyonline.com/lcgc/News/Singapore-manufacturing-facility/ArticleStandard/Article/detail/697310?contextCategoryId=38978&ref=25 Agilent Technologies has announced the opening of a new life sciences instrument manufacturing facility in Singapore. The facility will produce the company's LC-MS instruments for the global market. 2010-12-03T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/482010/697310null HTML http://www.chromatographyonline.com/lcgc/Industry%3A+Biological/Characterization-of-Monoclonal-Antibodies/ArticleStandard/Article/detail/702324?contextCategoryId=38978&ref=25 The advantages of HPLC-Chip-MS workflow over conventional methods of N-glycan analysis 2010-11-19T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/032011/702324/gudihalthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/032011/702324/gudihalflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/PerkinElmer---Rapid-UHPLC-Determination-of-Preserv/ArticleStandard/Article/detail/694847?contextCategoryId=38978&ref=25 PerkinElmer - Rapid UHPLC Determination of Preservatives in Cosmetics 2010-11-10T05:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/462010/694847null HTML http://www.chromatographyonline.com/lcgc/Column%3A+LC+Troubleshooting/UHPLC-Tips-and-Techniques/ArticleStandard/Article/detail/697435?contextCategoryId=38978&ref=25 John Dolan presents some practical pointers to get the most out of your UHPLC system. 2010-11-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/482010/697435/LCTrub_Icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/482010/697435/LCTrub_Icon_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Articles/Improving-HPLC-Separation-of-Polyphenols/ArticleStandard/Article/detail/697437?contextCategoryId=38978&ref=25 This article highlights a number of recent developments in HPLC for polyphenol analysis. 2010-11-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/482010/697437null XML http://www.chromatographyonline.com/lcgc/Industry%3A+Biological/Simultaneous-Determination-of-Formononentin-Biocha/ArticleStandard/Article/detail/704023?contextCategoryId=38978&ref=25 A simple and rapid HPLC method was established to simultaneously determine the active ingredients of red clover. 2010-11-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/042011/704023null XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Are-Method-Requirements-Reasonable/ArticleStandard/Article/detail/704027?contextCategoryId=38978&ref=25 If something doesn't look right you need to investigate! 2010-11-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/042011/704027null XML http://www.chromatographyonline.com/lcgc/Column%3A+Column+Watch/Performance-Optimization-in-HPLC/ArticleStandard/Article/detail/697438?contextCategoryId=38978&ref=25 The guest authors describe an optimization procedure to achieve the highest plate count in a given analysis time. 2010-11-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/482010/697438/CW_icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/482010/697438/CW_icon_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Towards-a-Universal-Detector-for-Small-Molecule-An/ArticleStandard/Article/detail/704029?contextCategoryId=38978&ref=25 Direct-Electron Ionization is a useful tool in LC–MS. This article discusses the potential of this technique as a universal detector for small molecule analysis and how to deal with matrix effects. 2010-11-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/042011/704029null XML http://www.chromatographyonline.com/lcgc/GC/The-QuEChERS-Revolution/ArticleStandard/Article/detail/704028?contextCategoryId=38978&ref=25 Ron Majors interviews the inventors of QuEChERS to explore the sucesses, challenges and future potential of this innovative sample preparation technique. 2010-11-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/042011/704028null XML http://www.chromatographyonline.com/lcgc/Column%3A+History+of+Chromatography/Evolution-of-Chromatography-One-Scientists-51-Year/ArticleStandard/Article/detail/697433?contextCategoryId=38978&ref=25 Industry veteran Thomas Beesley takes readers on a tour of his experiences in chromatography. 2010-11-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/482010/697433/HistoryChrom_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/482010/697433/HistoryChrom_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Industry%3A+Biological/All-Ions-Quantification-Using-LC-MS/ArticleStandard/Article/detail/695636?contextCategoryId=38978&ref=25 Accurate and sensitive all-ions quantification using ultra-high resolution LC-MS 2010-10-22T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/472010/695636/sandersthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/472010/695636/sandersflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Market-Profile-UHPLC/ArticleStandard/Article/detail/695649?contextCategoryId=38978&ref=25 Ultra high performance liquid chromatography (UHPLC) systems, also referred to as fast LCs, are designed to take full advantage of smaller particles (sub 2 ?m), which yield higher resolution and increased sensitivity. 2010-10-22T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/472010/695649null HTML http://www.chromatographyonline.com/lcgc/GC/The-Best-of-Both-Worlds/ArticleStandard/Article/detail/692502?contextCategoryId=38978&ref=25 Speaking to Konik-Tech about the development of a new system combining LC and GC technology. 2010-10-08T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/442010/692502/Konikthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/442010/692502/Konikflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/SRM-and-H-SRM-on-an-Integrated-UHPLC-MS-Platform/ArticleStandard/Article/detail/692501?contextCategoryId=38978&ref=25 Using SRM and H-SRM on an Integrated UHPLC-MS Platform for Sensitive, Accurate and Reproducible Quantification of Perfluorinated Compounds in Human Breast Milk. 2010-10-08T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/442010/692501/guthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/442010/692501/guflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Improving-HPLC-Separation-of-Polyphenols/ArticleStandard/Article/detail/691153?contextCategoryId=38978&ref=25 Practical HPLC, HILIC and RP-LC methods of analysing common food and beverages containing polyphenols are presented. 2010-10-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/422010/691153/mondellothumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/422010/691153/mondelloflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Column%3A+LC+Troubleshooting/Are-the-Method-Requirements-Reasonable/ArticleStandard/Article/detail/691673?contextCategoryId=38978&ref=25 John Dolan discusses an inquiry he received from a reader complaining about the difficulty he was having meeting system suitability for an LC method that had been transferred into his lab. 2010-10-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/432010/691673/LCTrub_Icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/432010/691673/LCTrub_Icon_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Column%3A+Innovations+in+HPLC/Seeing-is-Believing-Detectors-for-HPLC/ArticleStandard/Article/detail/691672?contextCategoryId=38978&ref=25 The principles and attributes of today's HPLC detectors are discussed, and the advantages and disadvantages of the various detectors are compared and contrasted. 2010-10-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/432010/691672/Innovat_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/432010/691672/Innovat_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Summer-Reflections-Part-1/ArticleStandard/Article/detail/688864?contextCategoryId=38978&ref=25 Incognito provides a retrospective account on subjects visited throughout the course of the year and asks if any problems have been addressed and what new problems have arisen. 2010-09-24T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/402010/688864/summerthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/402010/688864/summerflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Meat-on-your-bones/ArticleStandard/Article/detail/686975?contextCategoryId=38978&ref=25 A study published in the Journal of Separation Science has looked at using the racemization of amino acids as a proxy for DNA preservation, giving archaeologists a rapid screening method for samples too badly damaged to extract. 2010-09-16T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/382010/686975null HTML http://www.chromatographyonline.com/lcgc/Industry%3A+Biological/Analysing-Red-Clover-by-HPLC/ArticleStandard/Article/detail/685044?contextCategoryId=38978&ref=25 A simple rapid HPLC method for simultaneously determiing formononetin, biochanin A, daidzen and genistein in Red Clover 2010-09-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/362010/685044/chenthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/362010/685044/chenflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Column%3A+LC+Troubleshooting/Speeding-Up-Gradients/ArticleStandard/Article/detail/688887?contextCategoryId=38978&ref=25 Guest author Stefan Brand and John Dolan take a look at how to speed up gradient separations while avoiding common errors. 2010-09-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/402010/688887/LCTrub_Icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/402010/688887/LCTrub_Icon_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Column%3A+Column+Watch/Highlights-of-HPLC-2010/ArticleStandard/Article/detail/688897?contextCategoryId=38978&ref=25 Ron Majors presents his yearly review of the HPLC Conference. 2010-09-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/402010/688897/CW_icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/402010/688897/CW_icon_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Where-Did-That-Peak-Come-From/ArticleStandard/Article/detail/689856?contextCategoryId=38978&ref=25 A broad peak where it does not belong is a classic sign of late elution. 2010-09-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/412010/689856null XML http://www.chromatographyonline.com/lcgc/Articles/Finding-the-Best-Separation-for-Enantiomeric-Mixtu/ArticleStandard/Article/detail/688895?contextCategoryId=38978&ref=25 The authors describe a study of screening procedures that demonstrated a relatively small set of columns can be used routinely. 2010-09-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/402010/688895/francothumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/402010/688895/francoflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/Articles/Bare-Silica-Has-a-Future-in-Supercritical-Fluid-Ch/ArticleStandard/Article/detail/688891?contextCategoryId=38978&ref=25 The authors compare five bonded phases with bare silica for the SFC separation of a 19-component mixture of polar analytes. 2010-09-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/402010/688891null XML http://www.chromatographyonline.com/lcgc/GC/Data-Handling-and-Validation-in-Automated-Detectio/ArticleStandard/Article/detail/689848?contextCategoryId=38978&ref=25 An overview of current chromatography-based food toxicant screening is presented. 2010-09-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/412010/689848null XML http://www.chromatographyonline.com/lcgc/Sample+Prep/Plasma-Analysis/ArticleStandard/Article/detail/683247?contextCategoryId=38978&ref=25 The analysis of clozapine and norclozapine in plasma using automated on-line sample preparation and LC–MS/MS 2010-08-06T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/342010/683247/morganthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/342010/683247/morganflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/Column%3A+History+of+Chromatography/Story-of-a-Recovering-Electrochemist/ArticleStandard/Article/detail/682843?contextCategoryId=38978&ref=25 Well-known industry veteran and LCGC EAB member Peter Carr looks back at the early days of the chromatography field and reflects on his own experiences. 2010-08-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/332010/682843/HistoryChrom_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/332010/682843/HistoryChrom_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Column%3A+LC+Troubleshooting/System-Contamination/ArticleStandard/Article/detail/682845?contextCategoryId=38978&ref=25 Deterioration of the separation can result from many causes. This month's column looks at some techniques to isolate the problem source. 2010-08-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/332010/682845/LCTrub_Icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/332010/682845/LCTrub_Icon_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Articles/Why-does-it-take-so-long-to-validate-a-CDS/ArticleStandard/Article/detail/682848?contextCategoryId=38978&ref=25 The author examines the process of validating a CDS and describes the trials along the way such as speed of validation, risk management, and so forth. 2010-08-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/332010/682848/mcdowallthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/332010/682848/mcdowallflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Peak-Integration-for-UHPLC/ArticleStandard/Article/detail/680470?contextCategoryId=38978&ref=25 UHPLC is fast becoming mainstream in many laboratories. With increased data, however, comes a directly proportional increase in data integration. 2010-07-23T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/312010/680470/quinnthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/312010/680470/quinnflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Liquorice-treats-Allsorts/ArticleStandard/Article/detail/679050?contextCategoryId=38978&ref=25 Weikang Bio-Technology Group, a Chinese manufacturer and marketer of traditional Chinese medicines, is launching a new project to research and develop liquorice flavonoids for use in therapeutics. For the study, the company reports that it intends to use supercritical carbon dioxide extraction technology to produce superior quality herbal extracts, column chromatography to isolate and purify compounds and HPLC to separate, identify and quantify compounds based on their idiosyncratic polarities. 2010-07-13T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/292010/679050null HTML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Global-Concerns-Drive-LC-Development/ArticleStandard/Article/detail/679044?contextCategoryId=38978&ref=25 Global health and safety concerns now play a key role in driving innovation of liquid chromatography systems and the uptake of advanced LC technology, such as UHPLC. 2010-07-02T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/292010/679044/goodmanthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/292010/679044/goodmanflash_flash.jpg HTML http://www.chromatographyonline.com/lcgc/Column%3A+Innovations+in+HPLC/Ion-Chromatography-An-Overview-and-Recent-Developm/ArticleStandard/Article/detail/680293?contextCategoryId=38978&ref=25 The basics of IC are reviewed and recent advances that may extend this technology to new applications are discussed. 2010-07-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/302010/680293/Innovat_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/302010/680293/Innovat_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/Column%3A+LC+Troubleshooting/Where-Did-That-Peak-Come-From/ArticleStandard/Article/detail/680296?contextCategoryId=38978&ref=25 John Dolan looks at a case in which the peak doesn't seem to belong with the neighboring peaks in the chromatogram. 2010-07-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/302010/680296/LCTrub_Icon_T_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/302010/680296/LCTrub_Icon_F_flash.jpg XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Where-Did-That-Peak-Come-From/ArticleStandard/Article/detail/679638?contextCategoryId=38978&ref=25 A broad peak where it doesn't belong is a classic sign of late elution. 2010-07-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/302010/679638/lctroublethumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/302010/679638/lctroubleflash_flash.jpg XML http://www.chromatographyonline.com/lcgc/LC%2FHPLC/Bare-Silica-Has-a-Future-in-Supercritical-Fluid-Ch/ArticleStandard/Article/detail/679637?contextCategoryId=38978&ref=25 SFC is now regarded as a modern normal phase LC technique prompting a re-examination of the role of bare silica as a useful stationary phase. 2010-07-01T04:00:00Z http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/302010/679637/taylorthumb_thumbnail.jpg http://www.chromatographyonline.com/lcgc/data/articlestandard/lcgc/302010/679637/taylorflash_flash.jpg XML