The Partition Coefficient (log P), Distribution Coefficient (log D) and Acid Dissociation Constant (pKa): Knowing Your Compound for Solid-Phase Extraction Method Development in Reversed-Phase Mode

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The Partition Coefficient (log P), Distribution Coefficient (log D) and Acid Dissociation Constant (pKa): Knowing Your Compound for Solid-Phase Extraction Method Development in Reversed-Phase Mode

Feb 1, 2012
By: Michael Rummel
The Column
Volume 8, Issue 2

Gathering information about the chemical and physical properties of target analytes is an essential step to effective solid-phase extraction (SPE) method development. Log P, log D and pKa are key analyte characteristics that can have a significant impact on the rapid success of reversed-phase SPE method development. This article explores the value of these chemical properties and demonstrates their importance in efficient reversed-phase SPE method development and optimization.

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