Cars, internet, airplanes, people, everything is getting faster, including chromatography. The ultimate goal for chromatographers is to be able to achieve analyses in shorter run times without compromising the resolution, efficiency, and sensitivity that is strived for during method development. The wide availability of modern stationary phase packing materials and column dimensions makes this goal achievable to all chromatographers without, necessarily, the need for expensive ultrahigh-performance liquid chromatography (UHPLC) equipment.
There are a few modifications which can be easily made, to both the HPLC system and column, which will achieve the desired goal of reduced analysis time. This article will provide some tips and tricks as well as detailing the theory behind the chromatography.
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