Current Articles - Chromatography Online
Current Articles

Fittings and Tubing for Ultrahigh-Pressure Liquid Chromatography

November 1, 2014

To obtain the best performance from your UHPLC system, you need the right tubing and fittings. Here is what you need to know.

Reversed-Phase HPLC Mobile-Phase Chemistry — Explained

November 1, 2014

An explanation of why HPLC eluent systems are designed as they are.

Rapid Sample Preparation and Fast GC–MS-MS for the Analysis of Pesticides and Environmental Contaminants in Fish

November 1, 2014

This method allows for quick sample preparation of fish samples for the fast analysis of almost 200 targeted contaminants, including PAHs, PCBs, PBDEs, and flame retardants.

Analysis of Complex Pharmaceuticals by Ultrahigh-Pressure Liquid Chromatography: Case Studies and Quality Control Implications

November 1, 2014

Experimental results and method validation data from two case studies of complex small-molecule pharmaceuticals illustrate the utility and advantages of UHPLC for quality control.

How Much Can I Inject? Part II: Injecting in Solvents Other than Mobile Phase

November 1, 2014

How large an injection can you make if the injection solvent is not matched to the mobile phase?

Finding a Needle in a Haystack

November 1, 2014

Here, we examine the various way that chromatographers and chromatography data-handling systems locate and measure peaks.

When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration

October 1, 2014

The top five adulterated foods, the latest contaminants found in them, and the methods to detect those compounds

How Much Can I Inject? Part I: Injecting in Mobile Phase

October 1, 2014

What symptoms might indicate we have an injection problem?

HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies

October 1, 2014

The latest approaches to antibody characterization go beyond ion-exchange, size-exclusion, and reversed-phase modes to make use of affinity, hydrophobic interaction, mixed-mode, and HILIC techniques.

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LCGC COLUMNISTS 2014

Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration


Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies


MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis


LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase


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