HPLC 2014 was held 11–15 May in New Orleans, Louisiana, USA, for the first time and much earlier than normal. This instalment
of "Column Watch" covers some of the technology and application advances presented at HPLC 2014. We review the overall liquid-phase
chromatographic trends, summarize the awards presented, and discuss the column technology highlights observed at the symposium.
The 41st International Symposium on High Performance Liquid Phase Separations and Related Techniques, which alternates between
Europe and North America, with occasional side meetings in Australia and Asia, was held 11–15 May in New Orleans, Louisiana
— its first time in the southern part of the United States. More affectionately known as HPLC 2014, the symposium is the premier
scientific event for bringing together the myriad techniques related to separations in liquid and supercritical fluid media.
Chaired by Professor J. Michael Ramsey of the University of North Carolina at Chapel Hill, USA, with the able assistance of
the symposium organizer Professor Edward Yeung of Iowa State University, USA, and Janet Cunningham of Barr Enterprises, HPLC
2014 assembled 770 delegates from 39 different countries around the world. This number included vendor representatives from
44 exhibitors for the three-day plus instrument, software, and consumables exhibition. The number of conferees was just over
half of the attendance at HPLC 2013 in Amsterdam, The Netherlands, and in line with the HPLC 2012 symposium held in Anaheim,
California, USA. For some reason, the number of delegates for the United States version of this meeting has fallen off in
recent times, perhaps analogous to the falloff in other analytical symposia such as Pittcon. However, other meetings such
as the American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics seem to be gathering
steam, undoubtedly driven by the recent surge in the use of mass spectrometry (MS) detection in chromatography and other analytical
The venue for HPLC 2014 was the New Orleans Hilton located right on the Mississippi River close to the convention centre where
Pittcon has been held many times. The five-day plus event had a total of 155 oral presentation in plenary talks and mostly
in three parallel sessions, which made it a bit difficult to cover topics of interest that often ran at the same time. Fortunately,
all three lecture halls were within a few feet of each other so getting from one session to another didn't pose much of a
problem. At HPLC a total of 425 posters were presented in sessions with 25 different themes. Posters were up for the entire
symposium so they could be viewed at almost any time of the day. With an ample social event schedule including three receptions
and a symposium dinner and party, 10 vendor workshops, eight tutorial educational sessions, and five short courses (held during
the previous weekend), attendees had their hands full deciding how to allocate their time. The tutorials were particularly
well attended, some with standing room only, and covered current topics such as troubleshooting method development, polymeric
monoliths, microfluidics, column myths, ultrahigh-pressure liquid chromatography (UHPLC) theory and practice, the effect of
dwell volume, ion chromatography versus electrophoresis, and new Food and Drug Administration (FDA) regulations affecting
high performance liquid chromatography (HPLC).
In this instalment, I present some scientific highlights of HPLC 2014. This report also covers the various awards and honourary
sessions that took place. Since it was virtually impossible for one person to adequately cover all oral and poster papers,
my coverage will reflect a somewhat personal bias.