LC–MS–Based Methods for Identifying Drugs of Abuse in Oral Fluids for Forensic Toxicology Applications - - Chromatography Online
LC–MS–Based Methods for Identifying Drugs of Abuse in Oral Fluids for Forensic Toxicology Applications

The Column
Volume 5, Issue 10, pp. 11-14

Forensic toxicology screening methods are widely used to test biological samples for the presence of pharmaceutical drugs as well as drugs of abuse and their metabolites. Screening has most commonly been performed on urine or blood samples, using immunoassays or gas chromatography coupled with mass spectrometry (GC–MS). However, these methods have various limitations that include risks of false positives and false negatives, lack of specif city, and limited throughput. Moreover, these methods are unable to keep up with continual developments relating to drug abuse. For example, they are not suitable for detecting drugs from numerous different classes simultaneously, and are not always easy to adapt for detecting new drugs. In recent years, forensic toxicology laboratories have begun developing liquid chromatography–mass spectrometry-based (LC–MS) methods for drug screening. This article reviews key developments and potential advantages of using LC–MS for forensic toxicology, including the option of using oral fluid samples.

Click here for the full article in The Column


blog comments powered by Disqus
LCGC E-mail Newsletters
Global E-newsletters subscribe here:



Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration

Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies

MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis

LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase

More LCGC Columnists>>

LCGC North America Editorial Advisory Board>>

LCGC Europe Editorial Advisory Board>>

LCGC Editorial Team Contacts>>

Source: The Column,
Click here