Wednesday, October 10, 2012
9:00am EST/15:00 CEST
ID and Quant for Proteomics with MaXis impact
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Mass spectrometry-based quantitative proteomics is a popular tool for both biomarker candidate discovery and validation. Recent advances in the speed, robustness, and quality of both chromatographic separation and mass spectrometric detection have enabled the subsequent validation of discovered protein biomarkers candidates in complex biological matrices using targeted approaches. These biomarker candidate validation approaches rely heavily on analytical strategies that isolate and quantify the signal relative to specific peptides and proteins in complex proteomic samples. Typically, SRM and MRM (selected- and multiple-reaction monitoring) approaches are applied for validation tasks. Nevertheless, those methods require detailed target knowledge, time-consuming method preparation and do not allow later post-analysis data mining. This event will discuss the use of the latest-generation instruments for both discovery and validation steps. The audience will find out how the combined advances in dynamic range, resolution and acquisition speed permit the use of Data Independent Analysis methods that enable users to avoid the tedious acquisition method design, and how the seamless integration with the latest data processing software enables rapid data valuation and reporting.
Sponsored by: Bruker