Pharmaceutical LC - - Chromatography Online
Pharmaceutical LC

Meeting Reports

Session 1050, Room S504bc, 8:30 a.m.

This Tuesday morning oral session will be presided over by Elizabeth Harris, of Mankind Corporation (Valencia, California).

The first presentation in this session will be from Lipika Basumallick, of Thermo Fisher Scientific (Waltham, Massachusetts) whose talk is titled “Ion Chromatography Assays for Ions in Adenosine – Possible Replacement for Color-Based Assays.” Basumallick will discuss the development of ion chromatography assays for ammonia, and for chloride and sulfate that meet the requirements of the adenosine monograph.

The next presentation in the session is titled “Determination of Morpholine in Linezolid by Ion Chromatography” and will be delivered by Yongjing Chen, of Thermo Fisher Scientific. Chen will discuss the need for a sensitive method to determine morpholine in synthetic drugs such as linezolid.

Following Chen, Xiaodong Liu, of Thermo Fisher Scientific, will present “A Platform HPLC Method for Pharmaceutical Counter Ion Analysis.” The presentation will describe a platform method for screening all pharmaceutical counter ions (for example, sodium, potassium, magnesium, calcium, chloride, bromide, nitrate, malate, citrate, sulfate, fumareate, citrate, and others).

Brian De Borba, of Thermo Fisher Scientific, will be the next presenter, with a talk titled “Development of an Assay for Besylate in Amlodipine Besylate by Ion Chromatography and a Second Assay to Simultaneously Determine Amlodipine and Besylate by HPLC.” De Borba will discuss the development of an isocratic ion chromatography method with suppressed conductivity detection for determining besylate in amlodipine besylate, and the development of a second method for the simultaneous determination of amlodipine and besylate using a tri-mode (reverse-phase, anion exchange, cation exchange) HPLC column with UV detection.

After a 15-minute recess, Hua Yang, of Thermo Fisher Scientific, will continue the session with a presentation of “Identification and Quantification of 22 Common Anions in Pharmaceuticals in a Single Run Using HPIC with Suppressed Conductivity and Charge Detection.” This study demonstrates the identification and quantification of 22 commonly found anions in pharmaceuticals in a single run using a high-pressure capillary IC system with 4 µm particle ion-exchange column, and CD/QD dual detectors.

Michael D. McGinley, of Phenomenex (Torrence, California) will present next on “A Rapid Novel Gel Filtration Solution for Determining Protein Aggregation.” Strategies for rapid method development using a new methodology and chromatography solution that provides a more accurate method for quantitating aggregate in protein solution will be discussed.

The next presentation, titled “Separation of Nucleotides by Hydrophilic Interaction Chromatography (HILIC) Using the FRULIC-N Column” will be by Zachary S. Breitbach, of the University of Texas at Arlington. Breitbach will explain how the thermodynamic characteristic of the FRULIC-N column was investigated by evaluating the column temperature effect on retention and using van’t Hoff plots.

Lawrence Y. Loo, of Phenomenex, will provide the session’s final presentation, titled “Coupling Efficiency and Selectivity for Unparalleled Resolving Power to Meet Today’s Chromatographic Challenges.” Loo will discuss a study that demonstrates the advantages of coupling core-shell technology with surface modification that can provide adequate selectivity even in difficult separations.


blog comments powered by Disqus
LCGC E-mail Newsletters
Global E-newsletters subscribe here:



Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration

Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies

MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis

LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase

More LCGC Columnists>>

LCGC North America Editorial Advisory Board>>

LCGC Europe Editorial Advisory Board>>

LCGC Editorial Team Contacts>>

Source: Meeting Reports,
Click here