Sample Preparation Techniques - Chromatography Online
Sample Preparation Techniques
LCGC editorial, peer-reviewed research articles, and opinion pieces covering sample preparation techniques.

"Just Enough" Sample Preparation: A Proven Trend in Sample Analysis

December 1, 2012

This article discusses the details of how the newer techniques of sample preparation are simplified by the use of LC–MS-MS and GC–MS-MS technology.

Advances in Sample Preparation for Food Analysis

May 1, 2012

Sample preparation is a crucial part of the analysis of foodstuffs. Current sample preparation techniques used in food analysis are reviewed and the advantages and drawbacks of each one are discussed.

Ultra-High Resolution Chromatography Using 500 mm UHPLC Columns for Detection Of Hidden Sample Components

April 19, 2012

LC method development for new drug candidates or screening methods for new active structures in botanicals present the same type of challenges: How do I know that I have separated all main components, as well as important, sometimes hidden, impurities? Is my resolution good enough? Am I missing small, co-eluting peaks?

Theoretical Concepts and Applications of Turbulent Flow Chromatography

March 1, 2012

Turbulent flow chromatography is often used for on-line sample cleanup of biological matrices in liquid chromatography–mass spectrometry applications.

Market Profile: Flash Chromatography

June 17, 2011

Flash chromatography is a type of preparative liquid chromatography commonly used in the separation of organic compounds.

Aggregated Singletons for Automated Purification Workflow

June 1, 2011

Aggregated singletons for automated purification workflow delivers 30 mM DMS solutions for biological screening.

Trichothecene Mycotoxins Analysis using a Modified QuEChERS Approach

May 27, 2011

The extraction, purification and simultaneous determination of five mycotoxins from wheat and corn is described using a modified QuEChERS approach with LC-MS determination. These include three type A, diacetoxyscirpenol (DAS), T-2 toxin and HT-2 toxin, and two type B trichothecenes, deoxynivalenol (DON) and nivalenol (NIV).

On-line Blood Analysis using Microextraction

April 1, 2011

Microextraction by packed sorbent is a sample preparation technique that can be connected on-line with LC or GC systems.

New Chromatography Columns and Accessories at Pittcon 2011: Part II

April 1, 2011

A review of the gas chromatography columns, sample preparation, and chromatographic and sample preparation accessories that were presented at Pittcon 2011.

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LCGC COLUMNISTS 2014

Sample Prep Perspectives | Ronald E. Majors: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments.
LATEST: UV Detector Problems


Perspectives in Modern HPLC | Michael W. Dong: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: Superficially Porous Particles: Perspectives, Practices, and Trends


MS — The Practical Art | Kate Yu: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis


LC Troubleshooting | John Dolan: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: Problems with Large-Molecule Separations


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