Pamela C. Iraneta

A discussion of different sample solvent compositions to be injected for SFC as part of injection linearity experiments

How ethylene-bridged hybrid inorganic-organic (BEH) particles are prepared, and how their special quallities can be used to improve separations.

How ethylene-bridged hybrid inorganic–organic (BEH) particles are prepared and how their special qualities can be used to improve separations

Despite recent advances in column technology and stationary phase chemistry, challenges still remain for routine method development and LC/MS applications.

Since the introduction of high-performance liquid chromatography (HPLC) nearly 40 years ago, many improvements have been made to column stationary phases to achieve faster, more efficient separations. HPLC columns containing superficially porous (sometimes called fused-core) particles have recently gained increasing attention. Though this technology is not entirely new, it has been improved to the point where rapid, highly efficient separations can be achieved for some applications.

The use of a silica column for HILIC is examined, including mechanistic studies of analyte retention on silica in aqueous-organic mobile phases.