Articles by John W. Dolan - Chromatography Online
Articles by John W. Dolan

John W. Dolan

"LC Troubleshooting" Editor

John Dolan has been writing "LC Troubleshooting" for LCGC for over 25 years. One of the industry's most respected professionals, John is currently a principal instructor for LC Resources, Walnut Creek, California He is also a member of LCGC's editorial advisory board.

Articles
How Much Can I Inject? Part II: Injecting in Solvents Other than Mobile Phase
November 1, 2014

How large an injection can you make if the injection solvent is not matched to the mobile phase?

How Much Can I Inject? Part 2: Injecting In Solvents Other Than Mobile Phase
November 1, 2014

How large an injection can you make if the injection solvent is not matched to the mobile phase?

How Much Can I Inject? Part I: Injecting in Mobile Phase
October 1, 2014

What symptoms might indicate we have an injection problem?

How Much Can I Inject? Part 1: Injecting in Mobile Phase
October 1, 2014

Both the volume of the sample injection and the solvent in which the sample is dissolved can affect the appearance of the chromatogram.

Estimating Resolution for Marginally Separated Peaks
September 1, 2014

How can resolution be determined when peak width cannot be measured?

Estimating Resolution for Marginally Separated Peaks
September 1, 2014

How can resolution be determined when peak width cannot be measured?

How Much Retention Time Variation Is Normal?
August 1, 2014

Small changes in retention time with an LC method are normal. At what point is a problem suggested?

How Much Retention Time Variation is Normal?
August 1, 2014

Small changes in retention time of a liquid chromatography (LC) method are normal. But at what point is a problem suggested? Retention time shifts can be frustrating when you can't figure out if a shift is something you caused or if there is another reason for it.

Mobile-Phase Degassing: What, Why, and How
July 1, 2014

Why should you be concerned about mobile-phase degassing?

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LCGC COLUMNISTS 2014

Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration


Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies


MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis


LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase


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