Articles by John W. Dolan - Chromatography Online
Articles by John W. Dolan

John W. Dolan

"LC Troubleshooting" Editor

John Dolan has been writing "LC Troubleshooting" for LCGC for over 25 years. One of the industry's most respected professionals, John is currently a principal instructor for LC Resources, Walnut Creek, California He is also a member of LCGC's editorial advisory board.

Articles
Estimating Resolution for Marginally Separated Peaks
September 1, 2014

How can resolution be determined when peak width cannot be measured?

Estimating Resolution for Marginally Separated Peaks
September 1, 2014

How can resolution be determined when peak width cannot be measured?

How Much Retention Time Variation Is Normal?
August 1, 2014

Small changes in retention time with an LC method are normal. At what point is a problem suggested?

How Much Retention Time Variation is Normal?
August 1, 2014

Small changes in retention time of a liquid chromatography (LC) method are normal. But at what point is a problem suggested? Retention time shifts can be frustrating when you can't figure out if a shift is something you caused or if there is another reason for it.

Mobile-Phase Degassing: What, Why, and How
July 1, 2014

Why should you be concerned about mobile-phase degassing — it's all done automatically, isn't it?

Mobile-Phase Degassing: What, Why, and How
July 1, 2014

Why should you be concerned about mobile-phase degassing?

UV Detector Problems
June 1, 2014

UV detectors are the most common LC detector, and perhaps the most reliable ones. But they are not without problems.

Problems with Large-Molecule Separations
June 1, 2014

Some attributes of large molecules make them behave differently from small molecules in reversed-phase separations.

UV Detector Problems
June 1, 2014

To solve problems with UV detectors, it helps to understand a few things about how the detector cells are designed.

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LCGC COLUMNISTS 2014

Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: Avoiding Reversed-Phase Chromatography Problems Through Informed Method Development Practices: Choosing the Stationary-Phase Chemistry


Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: Seven Common Faux Pas in Modern HPLC


MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis


LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: Estimating Resolution for Marginally Separated Peaks


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