Howard G. Barth

In this month's column, Howard Barth traces the early development of SEC

Howard G. Barth and Ronald E. Majors Liquid–solid extraction is the most popular method, but sometimes modern approaches such as PLE/ASE and MAE are possible.

This instalment focuses on approaches and techniques for extracting and concentrating small molecules of interest present in polymeric materials.

A comprehensive review of standard and specialty SEC columns, including up-to-date charts and advice on how to choose

The fundamentals of size-exclusion chromatography, packing properties, and practical approaches for increasing resolution

The results of a study to determine the influence of SEC column order on molecular size separation and peak broadening

Although size exclusion chromatography (SEC) is a fairly mature separation technique, improvements are continually made in packing technology. Howard Barth and Greg Saunders review some of the basics of SEC and look at the current status of column technology, including developments for faster and higher resolution size separations.