Articles by Tony Taylor - Chromatography Online
Articles by Tony Taylor

Tony Taylor


Tony Taylor is the technical director of Crawford Scientific and ChromAcademy. He comes from a pharmaceutical background and has many years research and development experience in small molecule analysis and bioanalysis using LC, GC, and hyphenated MS techniques. Taylor is actively involved in method development within the analytical services laboratory at Crawford Scientific and continues to research in LC-MS and GC-MS methods for structural characterization. As the technical director of the CHROMacademy, Taylor has spent the past 12 years as a trainer and developing online education materials in analytical chemistry techniques.

Articles
The LCGC Blog: Avoiding the Problems Associated with HPLC Column Overload
July 17, 2014

Much has been written about column overload, however, I've seen many instances lately in which overload may not be instantly recognized, or causes problems that may not normally be attributed to overload. Therefore, I wanted to explain how to spot and deal with different types of overload situations.

The LCGC Blog: Chromatography Technical Tips - Robustness in HPLC Eluents
June 9, 2014

When developing a separation, some fundamental choices need to be made on how we might achieve the separation we require - primarily the mode of chromatography used and the way in which we intend to control and optimise the retention and separation (selectivity) of analyte components.

The LCGC Blog: GC Inlet Maintenance...have you really heard it all before?
May 15, 2014

Many troubleshooting investigations in chromatography often don?t lead to a single causal factor. Often, the reason for problems or lack of method robustness are related to many small ?contributory factors? and this is particularly true of the problems associated with sample introduction in capillary Gas Chromatography.

The LCGC Blog: Capillary GC Liner Selection Guide
April 17, 2014

This blog attempts to provide an impartial guide to liner selection which is representative of the considerations in modern capillary GC.

The LCGC Blog: Diode Array Detector Settings - Five Minutes to Change Your Chromatography Forever
March 20, 2014

Of late we have been running a series called 'Lock and Leave', which serves as a reminder to pay attention to those instrument parameters which are often overlooked - you know the type of thing ? 'that's the best value for this system?, 'we always set to that value' and 'I have no idea what that does' ? it's always at that value'.

The LCGC Blog: Measuring Quality...
February 20, 2014

Surrogates, Internal Standards, Isotopically labelled Standards, External Standards, Calibrants, QC Samples etc. etc. - our working lives are littered with checks to ensure that our instruments are giving us the correct results. And rightly so. But do we always use these checks correctly? Do we know what we are checking and why? Indeed, do we know how to design methods/procedures which employ a valid checking regime, often referred to as a Quality System? Let's find out.

The LCGC Blog: HPLC Filtration - Rocks, Boulders, and Sand
January 23, 2014

An assembly of thoughts on all things filtration for HPLC - and how to deal with various nasties - from Rocks to Sand.

The LCGC Blog: The Heat is On! Insights into a More Logical Approach to GC Temperature Program Development
December 19, 2013

There has been much focus within the industry of late on ways of improving the way in which HPLC method development is carried out - which has led to a more widespread adoption of modelling and optimisation software combined with dedicated method development platforms from the major instrument vendors.

The LCGC Blog: Split Later and the Case of the Infinite Dilution Tube
November 19, 2013

No, this isn't a new detective novel, in fact its two concepts which were "coined" by my good friend John Hinshaw during a recent CHROMacademy webcast which we presented together on sample introduction for capillary GC.

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LCGC COLUMNISTS 2014

Sample Prep Perspectives | Ronald E. Majors: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments.
LATEST: UV Detector Problems


Perspectives in Modern HPLC | Michael W. Dong: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: Superficially Porous Particles: Perspectives, Practices, and Trends


MS — The Practical Art | Kate Yu: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis


LC Troubleshooting | John Dolan: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: Problems with Large-Molecule Separations


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