Articles by Tony Taylor - Chromatography Online
Articles by Tony Taylor

Tony Taylor

Tony Taylor is the technical director of Crawford Scientific and ChromAcademy. He comes from a pharmaceutical background and has many years research and development experience in small molecule analysis and bioanalysis using LC, GC, and hyphenated MS techniques. Taylor is actively involved in method development within the analytical services laboratory at Crawford Scientific and continues to research in LC-MS and GC-MS methods for structural characterization. As the technical director of the CHROMacademy, Taylor has spent the past 12 years as a trainer and developing online education materials in analytical chemistry techniques.

The LCGC Blog: Are we scared to properly explore selectivity options in HPLC?
November 20, 2014

Much has been written about options for increasing efficiency in HPLC ? primarily through the use of core shell and sub 2 ?m particles, which have been used to increase efficiency, speed up separations or increase peak capacity. However, many separations can only be effectively improved, by optimising selectivity ? resolution is a function of selectivity, efficiency and retention, with selectivity being the most effective at achieving good resolution.

The LCGC Blog: Chromatography Technical Tips - Polar Analyte Retention and Phase Collapse
October 16, 2014

Why would one want to use a mobile phase containing 100% water? Usually to wash the analyte or old mobile phase from the column (stationary phase surface) or to help retain analytes which elute quickly using mobile phases containing only very small amounts of organic solvent (usually highly polar analytes).

Critical Evaluation of GC Methods
October 1, 2014

How to spot weaknesses in methods before problems occur

The LCGC Blog: So Just How Well Set-Up is Your UV Detector?
September 18, 2014

Most of us who have used UV detection for HPLC analyses consider them very straightforward and find they produce fit for purpose data whenever we need them to.

The LCGC Blog: Capillary GC Liner Selection Guide
September 8, 2014

LCGC Blogger Tony Taylor provides his impartial guide to liner selection that is representative of the considerations in modern capillary gas chromatography (GC).

Critical Evaluation of HPLC Methods
September 1, 2014

An investigation into some "typical" HPLC method specifications to highlight ways of critically evaluating the major and minor parameters of a method

The LCGC Blog: Putting the U into Your UHPLC
August 21, 2014

Tony Taylor discusses the importance of keeping extra column volume as small as possible, especially when using UHPLC equipment.

Modern Mass Spectrometry in Protein Analysis
August 1, 2014

An overview of the analytical approaches used for the analysis of biomolecules

The LCGC Blog: Robustness in HPLC Eluents
July 24, 2014

Is 0.1% TFA (aq) / 0.1% TFA in acetonitrile the ultimate robust HPLC mobile phase? Maybe not...


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Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration

Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies

MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis

LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase

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