Articles by Tony Taylor - Chromatography Online
Articles by Tony Taylor

Tony Taylor

Tony Taylor is the technical director of Crawford Scientific and ChromAcademy. He comes from a pharmaceutical background and has many years research and development experience in small molecule analysis and bioanalysis using LC, GC, and hyphenated MS techniques. Taylor is actively involved in method development within the analytical services laboratory at Crawford Scientific and continues to research in LC-MS and GC-MS methods for structural characterization. As the technical director of the CHROMacademy, Taylor has spent the past 12 years as a trainer and developing online education materials in analytical chemistry techniques.

The LCGC Blog: Chromatography Technical Tips - Polar Analyte Retention and Phase Collapse
October 16, 2014

Why would one want to use a mobile phase containing 100% water? Usually to wash the analyte or old mobile phase from the column (stationary phase surface) or to help retain analytes which elute quickly using mobile phases containing only very small amounts of organic solvent (usually highly polar analytes).

The LCGC Blog: So Just How Well Set-Up is Your UV Detector?
September 18, 2014

Most of us who have used UV detection for HPLC analyses consider them very straightforward and find they produce fit for purpose data whenever we need them to.

The LCGC Blog: Capillary GC Liner Selection Guide
September 8, 2014

LCGC Blogger Tony Taylor provides his impartial guide to liner selection that is representative of the considerations in modern capillary gas chromatography (GC).

The LCGC Blog: Putting the U into Your UHPLC
August 21, 2014

Tony Taylor discusses the importance of keeping extra column volume as small as possible, especially when using UHPLC equipment.

The LCGC Blog: Robustness in HPLC Eluents
July 24, 2014

Is 0.1% TFA (aq) / 0.1% TFA in acetonitrile the ultimate robust HPLC mobile phase? Maybe not...

The LCGC Blog: Avoiding the Problems Associated with HPLC Column Overload
July 17, 2014

Much has been written about column overload, however, I've seen many instances lately in which overload may not be instantly recognized, or causes problems that may not normally be attributed to overload. Therefore, I wanted to explain how to spot and deal with different types of overload situations.

The LCGC Blog: Chromatography Technical Tips - Robustness in HPLC Eluents
June 9, 2014

When developing a separation, some fundamental choices need to be made on how we might achieve the separation we require - primarily the mode of chromatography used and the way in which we intend to control and optimise the retention and separation (selectivity) of analyte components.

The LCGC Blog: GC Inlet Maintenance...have you really heard it all before?
May 15, 2014

Many troubleshooting investigations in chromatography often don?t lead to a single causal factor. Often, the reason for problems or lack of method robustness are related to many small ?contributory factors? and this is particularly true of the problems associated with sample introduction in capillary Gas Chromatography.

The LCGC Blog: Capillary GC Liner Selection Guide
April 17, 2014

This blog attempts to provide an impartial guide to liner selection which is representative of the considerations in modern capillary GC.


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Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration

Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies

MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis

LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase

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