Articles by Bethany Degg - Chromatography Online
Articles by Bethany Degg

Bethany Degg

Assistant Editor

Articles
Meat Authentication Using HPLC–MS–MS
October 6, 2014

Researchers from the Institute of Food Chemistry at Westfälische Wilhelms‑Universität Münster in Germany have developed an optimized high performance liquid chromatography coupled with mass spectrometry (HPLC–MS–MS) method using multiple reaction mode (MRM) and MRM3 for detecting horse and pork in highly processed food.

Capillary Electrophoresis Applied to Cystic Fibrosis Diagnosis
October 6, 2014

Scientists from CEITEC Masaryk University are collaborating with clinicians from the Department of Respiratory Diseases and TB at the University Hospital Brno (Brno, Czech Republic) to improve the diagnosis of cystic fibrosis, specifically in newborn babies. In a new study published in the Journal of Chromatography A, a new "skin wipe" sweat sampling method is presented that reduces the time required for sampling to under a minute and utilizes capillary electrophoresis (CE) to simultaneously determine chloride, sodium, and potassium ions in sweat samples.

Detecting Microbial Compounds in Waterpipe Smoke
September 19, 2014

Waterpipes have been used to smoke tobacco and other substances for more than four centuries, and are widely believed to be less harmful than cigarettes. In a new study published in the journal Science of the Total Environment, gas chromatography coupled to mass spectrometry (GC–MS–MS) was performed to show that waterpipe smoke can contain potentially harmful microbial compounds.

Improving MEKC–ESI–MS–MS Analysis of Synthetic Cathinones
September 19, 2014

A team of scientists based in the Czech Republic has developed a micellular electrokinetic chromatography method coupled with tandem mass spectrometry (MEKC–ESI–MS–MS) that uses salts of perfluorocarboylic acid as the volatile background electrolyte (BGE). The method was applied to the determination of 12 drugs from the class of synthetic cathinones in urine samples. According to the paper published in the Journal of Chromatography A, the BGE used to form micelles did not affect the electron ionization efficiency of MS. (1)

Analysis of Breast Milk to Determine Agent Orange Exposure
September 19, 2014

Scientists in Vietnam have performed high-resolution gas chromatography coupled with high-resolution mass spectrometry (HRGC–HRMS) analysis of breast milk to determine the level of dioxin and furan exposure around the Da Nang Agent Orange hotspot in Vietnam. Agent Orange contamination is associated with elevated and persistent levels of dioxins and furans in the environment and are associated with the occurrence of birth defects among other side effects.

Chiral Separation of I-MAMP and d-MAMP in Saliva
September 11, 2014

Saliva is becoming ever more commonly used in drug testing over urine or blood samples because of its ease of collection. As such, existing testing methods are being adapted for application to accommodate a change in sample matrix. In a new study published in the Journal of Chromatography A, scientists from the National Institute on Drug Abuse (Maryland, USA) and the University of Maryland Baltimore (Maryland, USA) present the use of precolumn derivatization using N(?)-(2,4-dinitro-5-fluorophenyl)-l-alaninamide (Marfey?s reagent) prior to liquid chromatography–mass spectrometry (LC–MS) analysis for the quantitation of chiral amphetamines in plasma and saliva.1

Type 2 Diabetes Bioactive Compounds in Rosemary and Mexican Oregano
August 22, 2014

A new study published in the Journal of Agricultural and Food Chemistry highlights the potential use of rosemary and oregano in the management of Type 2 diabetes mellitus (T2DM).

Insight into Diet of Neanderthals by GC–MS Analysis of Faeces
August 22, 2014

Scientists from the Massachusetts Institute of Technology (MIT) in Massachusetts, USA, and University of La Laguna in Spain, have performed gas chromatography–mass spectrometry (GC?MS) analysis of Neanderthal faeces to demonstrate that Neanderthals could have eaten fruit and vegetables and were not necessarily dependent on a meat diet. According to the study published in the journal PLOS ONE, this is significant because it is thought that the specific diet of Neanderthals could have contributed towards the species extinction.

Slower Py–GC–MS Unravels Cross-link Relationship in Amber
August 8, 2014

Amber is formed from plant resin that has polymerized and fossilized to form a resilient natural polymer. Jennifer Poulin and Kate Helwig, conservation scientists from the Canadian Conservation Institute in Ottawa, Canada, have developed a novel pyrolysis gas chromatography–mass spectrometry (py-GC–MS) method to characterize the structure of Class I amber that could be applied to other natural polymeric structures. Published in the journal Analytical Chemistry, the method demonstrates how a slower py-GC–MS technique can be performed to analyze natural polymers that contain cross-linked chemical moieties.

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LCGC COLUMNISTS 2014

Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration


Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies


MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis


LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase


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