Articles by Bethany Degg - Chromatography Online
Articles by Bethany Degg

Bethany Degg

Assistant Editor

Profiling Alzheimer's Disease Biomarkers in Blood Serum
November 20, 2014

Alzheimer?s Disease (AD) is one of the most common neurodenerative disorders worldwide. It is a progressive disorder characterized by gradual loss of mental ability associated with the death of brain cells, and is diagnosed using a combination of physical, neurological, and laboratory tests. Although there are no curative treatments available, early treatment can reduce the rate of the disease progression. Scientists from the University of Huelva and the Neurological Service from the Hospital Juan Ram?n Jim?nez in Spain, began collaborating four years ago to develop new strategies to identify biomarkers that could be used to speed up diagnosis of the disease. In a new study published in the journal Electrophoresis, the team present a metabolomics approach based on ultrafiltration followed by capillary electrophoresis coupled with mass spectrometry (CE?ESI?MS) for the fingerprinting of polar metabolites in blood serum.

Monitoring Plastic Exposure in Seabirds
November 20, 2014

Researchers from CSIRO Oceans and Atmosphere Flagship in Hobart, Australia, have published a new approach to monitoring plastic exposure in live birds. Featured in the journal Methods in Ecology and Evolution, the study describes the sampling of preen oil collected from seabirds using a simple swabbing method for gas chromatography coupled to mass spectrometry (GC–MS) analysis.1

Analyzing Dolphin Breath
November 7, 2014

A new study published in the journal Analytical Chemistry by scientists from the University of California Davis, the National Marine Mammal Foundation, and the Chicago Zoological Society in the USA presents a novel breath analysis method for Atlantic bottlenose dolphins (Tursiops truncatus) that could be used to monitor and assess the health of wild marine mammal populations.

Sample Amount Normalization in Metabolomics
October 24, 2014

A simple dansylation metabolite assay (DMA) for sample normalization that is similar to the bicinchoninic acid (BCA) protein assay widely used in proteomics has been presented in the journal Analytical Chemistry. The DMA assay is performed following sample extraction to determine the total metabolite concentration, which can then be used to determine the volume of sample needed to ensure that all samples contain the same concentration of metabolites.

Foodomics Approach Detects Anticancer Polyphenols in Rosemary
October 24, 2014

A study published in the journal Analytical Chemistry presents the application of a foodomics approach – combining transciptomics with metabolomics – to determine the anticancer mechanism of action of polyphenols contained in Rosmarinus officinalis L., commonly known as rosemary.1

Handmade Sea Salt Markers
October 24, 2014

A new study to be published in the journal Food Chemistry proposes 10 compounds that could be used to determine the authenticity of handmade sea salt opposed to industrial sea salt.

Meat Authentication Using HPLC–MS–MS
October 6, 2014

Researchers from the Institute of Food Chemistry at Westfälische Wilhelms‑Universität Münster in Germany have developed an optimized high performance liquid chromatography coupled with mass spectrometry (HPLC–MS–MS) method using multiple reaction mode (MRM) and MRM3 for detecting horse and pork in highly processed food.

Capillary Electrophoresis Applied to Cystic Fibrosis Diagnosis
October 6, 2014

Scientists from CEITEC Masaryk University are collaborating with clinicians from the Department of Respiratory Diseases and TB at the University Hospital Brno (Brno, Czech Republic) to improve the diagnosis of cystic fibrosis, specifically in newborn babies. In a new study published in the Journal of Chromatography A, a new "skin wipe" sweat sampling method is presented that reduces the time required for sampling to under a minute and utilizes capillary electrophoresis (CE) to simultaneously determine chloride, sodium, and potassium ions in sweat samples.

Analysis of Breast Milk to Determine Agent Orange Exposure
September 19, 2014

Scientists in Vietnam have performed high-resolution gas chromatography coupled with high-resolution mass spectrometry (HRGC–HRMS) analysis of breast milk to determine the level of dioxin and furan exposure around the Da Nang Agent Orange hotspot in Vietnam. Agent Orange contamination is associated with elevated and persistent levels of dioxins and furans in the environment and are associated with the occurrence of birth defects among other side effects.


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