LCGC North America, Apr 1, 2007 - Chromatography Online
LCGC North America, Apr 1, 2007
Variability - How to Control It
By John W. Dolan
Prompted by a recently reviewed manuscript and a question from a reader, John Dolan examines the variability of retention times observed in LC methods in this month's installment of "LC Troubleshooting."
Emanuel Gil-Av and the Separation of Enantiomers on Chiral Stationary Phases by Chromatography
By Leslie S. Ettre
Guest columnist Volker Schurig discusses the achievements of Emanuel Gil-Av in introducing enantioselectivity into chromatographic analysis.
Column Watch Column
New Chromatography Columns and Accessoies at Pittcon 2007: Part II
By Ronald E. Majors
This month's installment of "Column Watch" is the conclusion of a two-part series in which columnist Ron Majors examines trends in column and sample prep introductions at Pittcon 2007.
MS - The Practical Art
Alternatives in the Face of Chemical Diversity
By Michael P. Balogh
In this month's "MS-The Practical Art," Michael Balogh takes a closer look at insight provided by Chuck McEwen regarding obstacles while using solvents.
Peaks of Interest
The Gold Editors' Choice Awards was presented to Waters Corporation (Waltham, Massachusetts) for the Synapt HD–MS system at Pittcon 2007 in Chicago, Illinois. Silver Awards were presented to Paraytec (York, United Kingdom) for the ActiPix and Thermo Fisher Scientific (San Jose, California) for the LTQ ETD system. Bronze Awards were presented to Bruker Optics (Billerica, Massachusetts) for the ALPHA FT-IR system and Horiba Jobin Yvon (Edison, New Jersey) for the Activa system.
Laboratory Information Management Systems
Today's laboratories are sophisticated, generate large amounts of data, and rely on electronic data collection and tracking via a laboratory information management system (LIMS).
High-Throughput Quantitative LC-MS-MS Assays by On-Line Extraction Using Monolithic Support
By Raymond N. Xu , Grace E. Kim , Brian Boyd , Jill Polzin , Matthew J. Rieser , Tawakol A. El-Shourbagy
LC-MS-MS has become a widely used technique for the fast and sensitive quantitation of small molecules. In this article, this approach has been extended to high-throughput quantitative LC-MS-MS analysis under GLP applications for a drug candidate in development from preclinical animal studies through clinical development.


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Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration

Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies

MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis

LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase

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