Engineers at the Massachusetts Institute of Technology (MIT), in Cambridge, Massachusetts, are designing a tiny sensor that can detect minute quantities of hazardous gases more efficiently and quickly than current devices on the market.
This article aims to demonstrate the unique capability of resin-based mixed-mode solid-phase extraction (SPE) to achieve efficient extraction of basic drugs from plasma. Optimized pore size of the method minimizes retention of high molecular weight matrix components present in the biological fluid samples. The interferences are removed, ensuring extremely clean extracts for subsequent liquid chromatography?mass spectrometry-mass spectrometry (LC-MS-MS) analysis.
Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: Seven Common Faux Pas in Modern HPLC