LCGC Asia Pacific, Mar 1, 2011

LC Troubleshooting

Selectivity in Reversed-phase LC Separations (Part 1): Solvent-type Selectivity

By John W. Dolan

This month's column examines important aspects of solvent selection and how this affects selectivity.

GC Connections

Hydrogen Carrier Gas and Vacuum Compensation

By John V. Hinshaw

John Hinshaw investigates the influence of choosing hydrogen gas on column selection and operation with direct-interface gas chromatography–mass spectrometry.

CE Currents

Analysis of Inorganic Anions by Capillary Electrophoresis

By Kevin Altria

Capillary Electrophoresis is useful for analysing simple inorganic anions in forensic, clinical and pharmaceutical applications.

Articles

The Preparative Use of Flow Field-Flow Fractionation

By Angelika Juliane Freitag , Katharina Wittmann , Gerhard Winter , Julia Myschik

Demonstrating that flow field-flow fractionation can separate protein aggregates for preparative and analytical purposes.

Food Metabolomics: Fact or Fiction?

By Leon Coulier , Albert Tas , Uwe Thissen

This article describes important aspects of food metabolomics using tomato paste as an example of this approach in practice.

Departments

Determination of 25-mono-hydroxy-vitamin D2 and D3 in Human Plasma Using a Symbiosis Pico System: ACN Free On-line SPE-LC–MS–MS

By Martin Sibum

Spark Holland Application Note

Improving Mass Load Capacity for Basic Compounds Using Charged Surface Hybrid (CSH) Technology Columns

By Kenneth J. Fountain , Hillary B. Hewitson

Waters Application Note

From the Editor

Developing Method Development

By Alasdair Matheson

If the art of method development is dying what can we do about it?

Column Watch

The Increasing Role of Superficially Porous Particles in HPLC

By Ronald E. Majors

A review of the development of superficially porous particles and what the latest advances in this technology offer chromatographers in practice.

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	Column Watch \| Ronald E. Majors Trends in Sample Preparation
	LC Troubleshooting \| John W. Dolan Gradient Elution, Part IV: Dwell-Volume Problems
	MS: The Practical Art \| Kate Yu Hydrogen Deuterium Exchange Mass Spectrometry: An Emerging Biophysical Tool for Probing Protein Behaviour and Higher-Order Structure
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