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Analysis of the State of the Art: Gas Chromatography Column Technology
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| By
Laura Bush
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In honor of LCGC's celebration of 30 years covering the latest developments in separation science, we asked a panel of experts to assess the current state of the art of gas chromatography (GC) column technology, and to try to predict how the technology will develop in the future.
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Analysis of the State of the Art: Gas Chromatography Instrumentation
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Laura Bush
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In honor of LCGC's celebration of 30 years covering the latest developments in separation science, we asked a panel of experts (listed in the sidebar) to assess the current state of the art of gas chromatography (GC) instrumentation and to try to predict how the technology will develop in the future.
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Analysis of the State of the Art: Liquid Chromatography Column Technology
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Laura Bush
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In honor of LCGC's celebration of 30 years covering the latest developments in separation science, we asked a panel of experts (listed in the sidebar) to assess the current state of the art of liquid chromatography (LC) column technology, and to try to predict how the technology will develop in the future. This article is part of a special group of articles covering the state of the art in sample preparation, gas chromatography (GC) columns, GC instrumentation, LC columns, and LC instrumentation.
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Analysis of the State of the Art: Liquid Chromatography Instrumentation
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Laura Bush
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In honor of LCGC's celebration of 30 years covering the latest developments in separation science, we asked a panel of experts (listed in the sidebar) about the current state of the art of high performance liquid chromatography (HPLC) instrumentation and how the technology will develop in the future.
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Understanding Ion-Exchange Chromatography
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Ion-exchange chromatography (IEC) is based on the different affinities of analyte and eluent counterions for the oppositely charged ionic functional groups on the stationary-phase surface of an exchange resin. Depending on the charge of the surface electrostatic groups, the resin could be either an anion exchanger (positively charged stationary phase) or a cation exchanger (negatively charged stationary phase).
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Analysis of the State of the Art: Sample Preparation
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Mary Ellen P. McNally
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Congratulations, LCGC, on 30 successful years of reporting on the current trends in chromatography. Certainly, this is an accomplishment that we in the separations community have enjoyed and benefited from, and we wish you many more happy years of success.
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From the Publisher
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LCGC's global online presence is an ever-growing aspect of this publication as we strive to bring our readers the knowledge they need in a timely manner.
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From the Editor
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Milestone events, like LCGC's celebration of 30 years of covering separation science, always prompt reflection on the past and consideration of what the future might hold. Thus, for this 30th anniversary issue, we turned to the experts in five key areas of our coverage: sample preparation, gas chromatography (GC) columns, GC instrumentation, liquid chromatography (LC) columns, and LC instrumentation. Now, in the special group of five articles in this issue, we bring you their perspectives on the state of the art: what the most important recent advances have been, where things stand today, and where the field is likely to go next.
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Plates Versus Selectivity: An Emerging Issue With Complex Samples
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Fred E. Regnier
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Smaller particles, increasingly clever ways to overcome mass transfer limitations, further reductions in plate height, shorter separation times, higher pressure, and enhanced peak capacity dominate thinking in the high performance liquid chromatography (HPLC) community today. For healthcare applications, however, we need to think differently about how to improve analytical separations.
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Peaks of Interest
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Agilent Collaborates to Identify Causes of Outbreaks
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Market Profile: UHPLC
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Ultrahigh-pressure liquid chromatography (UHPLC) systems are designed to take full advantage of smaller particles (sub-2-?m), which yield higher resolution and increased sensitivity. Because of increased back-pressure, UHPLC systems use high-performance pumps that deliver pressures of 15,000 psi (1000 bar) or higher. Some systems solve the back-pressure issue by elevating temperatures using a column oven, which lowers the viscosity of the mobile phase and allows it to move faster through the column. UHPLC systems have been shown to provide analysis times of less than 1 min and up to 40 times faster than conventional HPLC systems.
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