LCGC North America, Oct 1, 2004 - Chromatography Online
LCGC North America, Oct 1, 2004
Sample Prep Perspectives
Practical Tips on Preparing Plasma Samples for Drug Analysis Using SPME
By Fernando M. Lanças , Maria Eugênia C. Queiroz
This month'ss guest authors review the application of solid-phase SPME to the analysis of drugs in human plasma.
Gradient Performance Checks
By Jonathan J. Gilroy , John W. Dolan
Just how good are your gradients?
GC Connections
Finding a Needle in a Haystack
By John V. Hinshaw
This month's "GC Connections" examines the various ways – and their attendant benefits and drawbacks – with which chromatographers and chromatography data-handling systems locate and measure peaks
Directions in Discovery
Coupling Capillary Isoelectric Focusing with Mass Spectrometry
By Tim Wehr
This month'ss "Directions in Discovery" column discusses current work in the use of capillary isoelectric focusing and mass spectrometry as a multidimensional separation technique for proteomic studies.
Hydrophilic Interaction Chromatography Using Silica Columns for the Retention of Polar Analytes and Enhanced ESI-MS Sensitivity
By Eric S. Grumbach , Diane M. Wagrowski-Diehl , Pamela C. Iraneta , Bonnie Alden , Jeffrey R. Mazzeo
The use of a silica column for HILIC is examined, including mechanistic studies of analyte retention on silica in aqueous-organic mobile phases.
Validation and Implementation of In-Process Control HPLC Assays for Active Pharmaceutical Ingredients
By P.W. Wrezel , M.S. Hussain , I. Chion
The authors describe a sensible approach for validation and implementation of HPLC IPC assays.


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Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration

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