Liquid Chromatography (LC/HPLC)

Nov 01, 2015
LCGC North America
Some new approaches can provide superior protein separations. These include using columns of highly efficient superficially porous silica particles and techniques involving MS-friendly mobile phases with effective methods for changing protein selectivity (band spacings) by column type and organic mobile-phase modifiers.
Nov 01, 2015
LCGC North America
So you think you know all about UV detection? Check your knowledge against this article on the principles and key variables of ultraviolet detection.
Nov 01, 2015
LCGC North America
At first, problems related to LC columns can be daunting. But if we have a technique to help simplify the troubleshooting process, the job can be much less intimidating.
Nov 01, 2015
LCGC North America
The column is at the core of chromatography, and the past 25 years have seen continuous improvements in HPLC and UHPLC columns. Here, Majors assesses the most important developments, looking at how we got this far and where we may be heading.
Oct 02, 2015
Special Issues
The use of off-line 2D-LC–MS for the characterization of HCPs and their monitoring during downstream processing.
Oct 02, 2015
Special Issues
The technical requirements for a successful LC–MS–MS method for the quantitation of biopharmaceuticals are presented and the advantages and disadvantages compared to ligand-binding assays are evaluated.
Oct 01, 2015
LCGC North America
Miniaturized separation techniques are advantageous for the analysis of illicit drugs and new psychoactive substances.
Oct 01, 2015
LCGC Europe
Solvent costs too high? Here are some ideas on how to decrease the amount of mobile phase you use.
Oct 01, 2015
LCGC Europe
This current paper provides useful tips for smooth validation of multi‑analyte LC–MS–MS methods and summarizes important validation outcomes for 295 analytes, including over 200 mycotoxins.
Sep 01, 2015
LCGC Europe
HPLC 2015, chaired by Gérard Hopfgartner was held in Geneva, Switzerland, from 21–25 June. This review covers some of the highlights of the symposium including stationary phase developments, particle technology, and growing application areas for HPLC.
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