Liquid Chromatography (LC/HPLC)

Sep 01, 2015
LCGC Europe
The authors present a method for comparing the levels of baseline interference arising from common laboratory mobile phase contamination sources and assess different approaches for removing dissolved contaminants to generate interference free chromatogram baselines. This article demonstrates that recirculating mobile phase through a semi-preparative scale column using a reagent delivery pump to be more effective than previously published mobile phase decontamination methods.
Sep 01, 2015
LCGC North America
Highlights from the symposium, including particle technology, stationary-phase developments, and growing application areas, as well as the trends and future perspectives we culled from the conference.
Aug 10, 2015
The Column
Automated high-throughput dynamic light scattering (HT–DLS) can enable rapid and unattended assessment of sample purity in biopharmaceutical samples, maximizing the reliability and productivity of the candidate selection process. This article explains more.
Jul 01, 2015
LCGC North America
Here, we concentrate on one particularly useful equation that allows us to make changes to an analytical system to improve throughput or efficiency, while retaining the selectivity of the original method.
Jul 01, 2015
LCGC North America
We consider the potential causes of peak distortion for the first two peaks in the chromatogram.
Jun 05, 2015
The Column
A selection of commonly asked questions about GPC/SEC from users.
Jun 01, 2015
LCGC North America
This work presents an on-line combination of a simple microgradient device for reversed-phase liquid chromatography (LC) and electrospray ionization (ESI) tandem mass spectrometry (MS-MS).
Jun 01, 2015
LCGC North America
Readers' questions regarding problems related to internal standard calibration of liquid chromatography methods are addressed.
Jun 01, 2015
LCGC North America
The use of superficially porous particles in the manufacture of high performance liquid chromatography (HPLC) columns has become prominent in recent years. Over the course of the past decade most major manufacturers have built column lines around the technology.
Jun 01, 2015
LCGC North America
This installment provides an overview of modern practices of high-throughput purification to support small-molecule drug discovery.
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