Mass Spectrometry

Mar 01, 2016
Special Issues
Enhanced chromatographic resolution (GC×GC), increased resolving power with high-resolution TOF-MS, and software designed to leverage these attributes are combined to provide data that are easy to process and interpret.
Mar 01, 2016
Special Issues
This article presents a step-by-step DoE optimization strategy for an electrospray ionization source with the aim to quantitatively analyze 18 compounds in a metabolomic study of human urine.
Mar 01, 2016
Special Issues
An LC–MS-MS method is presented that can assist with monitoring substance abuse patients who are prescribed naltrexone, a narcotic antagonist.
Mar 01, 2016
LCGC North America
When monitoring toxic gases emitted from the soil, it is often necessary to recover compounds with a boiling point above that of napthalene. The use of thermal desorption makes that possible.
Dec 01, 2015
Spectroscopy
By LCGC Editors
Imaging techniques using vibrational spectroscopy, MS, and atomic force microscopy have all been advancing and gaining momentum in recent years. There is great potential power in these imaging techniques, particularly in the biomedical field. Here, Thomas Bocklitz of the Friedrich-Schiller- University Jena discusses his work combining these techniques.
Dec 01, 2015
LCGC North America
The power of nontargeted metabolite profiling is illustrated in a study focused on the determination of molecular markers in malting barley.
Oct 03, 2015
Special Issues
Is your swimming pool clean and safe? Recreational water illness, most commonly in the form of digestive tract illness or skin, ear, or respiratory infections, is often caused by water contamination. The authors present a robust method, using solid-phase extraction and high-resolution mass spectrometry, for monitoring swimming pool water.
Oct 02, 2015
Special Issues
Recent progress in high-resolution mass spectrometry (HRMS) and liquid chromatography–mass spectrometry (LC–MS) methods for the structural characterization of brentuximab vedotin and trastuzumab emtansine are presented.
Oct 02, 2015
Special Issues
An outline of the basic principles of MS techniques used to investigate higher order structural features of biopharmaceuticals, as well as some insights into applications relevant to the pharmaceutical industry.
Oct 01, 2015
Special Issues
Do the signal-to-noise ratios presented by instrument vendors accurately reflect improvements in mass spectrometers? We review factors influencing the validity of vendor SNR specifications, and argue that the statistical alternative of instrument detection limits is more consistent with regulatory guidelines and a more relevant indicator of instrument performance.
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