Mass Spectrometry

Oct 01, 2015
Special Issues
An analytical methodology for the characterization of the primary structure of biotherapeutic proteins using sheathless CE–ESI-MS-MS instrumentation is presented. For the first time, complete sequence coverage can be achieved using a bottom-up proteomic approach from a single analysis of a tryptic digest. In a biosimilarity assessment, a single amino acid substitution was detected.
Oct 01, 2015
Special Issues
Do the signal-to-noise ratios presented by instrument vendors accurately reflect improvements in mass spectrometers? We review factors influencing the validity of vendor SNR specifications, and argue that the statistical alternative of instrument detection limits is more consistent with regulatory guidelines and a more relevant indicator of instrument performance.
Oct 01, 2015
Special Issues
Is your swimming pool clean and safe? Recreational water illness, most commonly in the form of digestive tract illness or skin, ear, or respiratory infections, is often caused by water contamination. The authors present a robust method, using solid-phase extraction and high-resolution mass spectrometry, for monitoring swimming pool water.
Oct 01, 2015
Special Issues
A method based on thermal desorption with gas chromatography–time-of-flight mass spectrometry (GC–TOF-MS) can elucidate how key volatiles vary with the size of the melon pieces. Such analytical information is of value in efforts to improve the quality and safety of ready-to-eat foods.
Oct 01, 2015
Special Issues
An analytical methodology for the characterization of the primary structure of biotherapeutic proteins using sheathless CE–ESI-MS-MS instrumentation is presented. For the first time, complete sequence coverage can be achieved using a bottom-up proteomic approach from a single analysis of a tryptic digest. In a biosimilarity assessment, a single amino acid substitution was detected.
Jul 07, 2015
The Column
Determining aroma compounds and off-flavours in edible oils by gas chromatography coupled to mass spectrometry (GC–MS) is routine in many food-producing companies; however, the oily matrix needs to be kept out of the analytical instrument to avoid impacting analytical stability. The following article describes a simple, yet efficient, way of eliminating the matrix while determining the flavour compounds in a sensitive and selective manner.
Jul 01, 2015
Special Issues
To translate the enormous potential of MS into meaningful, actionable, and safe test results in the specific setting of a clinical laboratory is a very substantial challenge. It is essential to realize that reliability is not inherent to this technology but must be addressed carefully and questioned systematically.
Jun 01, 2015
LCGC North America
We have developed a miniaturized, multifunctional device, called the "Single-Probe," that is capable of probing small targets and of sampling and ionizing molecular species.
May 01, 2015
Special Issues
By LCGC Editors
Bryan Vining from SGS Environmental Service in Wilmington, North Carolina, reveals some of the cutting-edge research his team has performed involving dioxin analysis, and proposes some future possibilities for the direction of this field.
May 01, 2015
Special Issues
Digital waveform technology is emerging as a powerful tool in mass spectrometry (MS). Digital quadrupoles rely on precise control of frequency rather than voltage, which allows these devices to access a greatly extended mass range
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