Ultra-HPLC (UHPLC) provides a new potential for method development and analysis. It is achieved by using a sub-2 µm particle size column packing at increased linear velocities. The advantage of UHPLC over conventional HPLC is the reduced analysis time without sacrificing efficiency. In comparison to traditional HPLC, analysis time can be decreased up to a factor of 7–10.
So the question for GPC/SEC users is: Can this approach be easily transferred to speed up GPC/SEC measurements? Unfortunately, the answer is: No — the UHPLC approach does not work! But there are other solutions to make GPC/SEC faster!