Special Issues November 2016

November 2016 | Volume 34, Issue 11
The recent trends in column technology for reversed-phase LC, SEC, ion-exchange chromatography, and HIC for analysis of biopharmaceuticals are critically discussed.
This article presents a selection of state-of-the-art analytical tools for mAb characterization and comparability assessment.
An outline of the basic principles of MS techniques used to investigate higher order structural features of biopharmaceuticals, as well as some insights into applications relevant to the pharmaceutical industry.
The use of off-line 2D-LC–MS for the characterization of HCPs and their monitoring during downstream processing
The technical requirements for a successful LC–MS/MS method for the quantitation of biopharmaceuticals are presented and the advantages and disadvantages compared to ligand-binding assays are evaluated.
An introduction from the guest editors of this special supplement
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