Frank David is a principal scientist at RIC group.
Separation Science: The State of the Art: How Mature is Gas Chromatography? An Industry Perspective
December 1st 2022In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.
Analysis of Ethylene Oxide and 2-Chloroethanol in Food Products: Challenges and Solutions
August 4th 2022The importance of accurate analysis methods for EtO and 2-CE in food is essential and the demand for robust methods that are able to deliver high sample throughput with minimal instrumental downtime is high.
On-Line Two-Dimensional Liquid Chromatography (2D-LC) for the Analysis of Pharmaceuticals
November 1st 2016On-line two-dimensional liquid chromatography (2D-LC) embracing mainly comprehensive LC (LC×LC) and multiple heart-cutting LC (mLC–LC) offers new opportunities for in-depth characterization of pharmaceuticals. Reversed-phase LC × reversed-phase LC using different column chemistries and mobile phases provides good orthogonality for a wide range of applications related to small molecule drugs. Moreover, hardware configurations and software are now commercially available to perform LC×LC and mLC–LC measurements in a reproducible manner.
Fast Determination of the Bitter and Clove-Like Flavour in Beer with the Agilent 1290 Infinity II LC
May 24th 2016In this application the Agilent 1290 Infinity II LC was used to determine the bitter compounds iso-alpha-acids and reduced iso-alpha-acids, and the clove-like phenolic flavor 4-vinylguaiacol in bottled beer.
Fast Determination of the Bitter and Clove-Like Flavor in Beer with the Agilent 1290 Infinity II LC
May 24th 2016In this application the Agilent 1290 Infinity II LC was used to determine the bitter compounds iso-alpha-acids and reduced iso-alpha-acids, and the clove-like phenolic flavor 4-vinylguaiacol in bottled beer.
Determination of Genotoxic Impurities in Pharmaceuticals
May 2nd 2013The determination of genotoxic impurities (GIs) in drug substances and pharmaceutical products is an emerging topic in pharmaceutical quality control. GIs are intermediates or reactants in the synthetic pathway of a drug substance and should be monitored at ppm (?g/g drug substance) or even ppb (ng/g) levels. This is several orders of magnitude lower than in classical impurity analysis (0.05% or 500 ppm level) or in residual solvent analysis. Analytical methods for the determination of GIs include gas chromatography (GC) and liquid chromatography (LC), both often combined with mass spectrometry (MS) detection. Some typical examples of GIs trace analysis using GC and LC are presented. The potential of on-line reaction monitoring is also discussed.
Ultralow Quantification of Pesticides in Baby Food
July 1st 2010The safety of the food that our children eat is a global concern. Regulations are in place that limit the maximum level of pesticides that can be present in food meant for children, and methods to detect levels well below those limits are needed to ensure the safety of the food supply. Combining the speed and separation efficiency of ultrahigh-pressure liquid hromatography (UHPLC) with the sensitivity and selectivity of triple-quadrupole mass spectrometry (MS)-MS results in a method that can deliver ultralow quantification of pesticides in baby food, with limits of detection more than an order of magnitude below the allowed maximum levels.