Giuseppe Astarita | Authors

Giuseppe Astarita is a principal scientist at Waters Corporation in Milford, Massachusetts, USA, and serves as adjunct professor at Georgetown University in Washington, D.C. Giuseppe’s research interests include lipid mass spectrometry and metabolomics, as applied to translational medicine and biomarker discovery. He is applying the latest technologies in the study of health and disease as well as food and nutrition. Direct correspondence to:


Desorption and Ionization Mass Spectrometry in Research Laboratories

The past decade has brought exponential growth in the number of mass spectrometry (MS) ionization techniques based on desorption and ionization (DI) processes. Here, the three key applications for DI are discussed: rapid, in situ screening; direct analysis of extracted samples or of planar chromatography spots; and scanning samples along x and y axes.

Ion-Mobility Mass Spectrometry in Metabolomics and Lipidomics

Ion-mobility spectrometry (IMS) is an analytical technique that provides for the separation of ions in the gas phase. The separation, occuring on a timescale of milliseconds, is based on the differing mobility of ions according to their charge, shape, and size. These characteristics make IMS suitable for coupling with mass spectrometry (MS), to serve in current MS-based workflows for metabolomics and lipidomics. IMS–MS improves peak capacity and signal-to-noise ratios, and it provides more confidence during compound identification or confirmation than conventional analyses.