New Mass Spectrometry Measurement Tools for Characterizing Individual Cells
New developments in measurement science are providing chemical information on single cells. Single-cell chemical assays provide unique information on cell heterogeneity and allow detailed studies of the metabolome and proteome for both snapshot and time-resolved studies. Recent papers describe multimodal chemical imaging, single-cell MALDI-MS supervised by immunocytochemical classification, integrating mass spectrometry with microphysiological systems for improved neurochemical studies, high throughput approaches, and others. This interview with Jonathan Sweedler explores the latest developments in mass spectrometry and separations for single cell analysis.