Michael W. Dong | Authors

This instalment is the first of a series of four white papers on high performance liquid chromatography (HPLC) modules (pump, autosampler, UV detector, and chromatography data system) to be published in 2019. This instalment provides an overview for analytical-scale HPLC pumps, including their requirements, modern designs, operating principles, trends, and best practices for trouble-free operation.

Wouldn’t it be nice if a single generic high performance liquid chromatography (HPLC) method could be used for all small molecule drugs - not only for potency assays but also for ICH-compliant stability-indicating assays?

New HPLC and MS systems: A review of instrumentation trends and the current market along with new instruments, modules, chromatography data systems, and related software.

This instalment describes high performance liquid chromatography (HPLC), mass spectrometry (MS), and related products introduced at Pittcon 2019 and during the year prior. It reviews new HPLC and MS systems, modules, chromatography data systems (CDS), and other related software and summarizes their significant features and user benefits. A brief description of instrumentation trends and the current market is also included.

This instalment provides an overview of the modern trends and best practices in mobile-phase selection for reversed-phase liquid chromatography (LC). In particular, we focus on selection criteria and rationales for enhancing analytical performance and ease of preparation.

This instalment describes ten corollaries in high performance liquid chromatography (HPLC) and pharmaceutical analysis that most practitioners are likely aware of but may overlook the rationales behind them.