M.J. Ruiz-Ángel | Authors

Departament de Química Analítica, Universitat de València, Valencia, Spain.


Micellar Liquid Chromatography: How to Start

Micellar liquid chromatography (MLC) is a reversed-phase liquid chromatographic mode with a solution of surfactant forming micelles as the mobile phase. The interaction of solutes with the stationary phase coated with surfactant monomers, combined with the increased solubilization capability of micelles, have profound implications with regard to retention, selectivity and efficiency. Practical steps that a chromatographer involved in MLC should consider when developing an analytical procedure are described, including mobile phase preparation, column conditioning and cleaning.

Photodegradation and Photostability Studies of Bendroflumethiazide (BFMT) in Pharmaceutical Formulations and Urine Samples by Micellar Liquid Chromatography

In this article, the authors present a simple high performance liquid chromatographic procedure for the determination of bendroflumethiazide (BFMT) in pharmaceutical formulations and urine samples. They demonstrate how the lack of an organic solvent in the mobile phase reduces the risk of environmental contamination and human toxicity.