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© 2020 MJH Life Sciences™ and Chromatography Online. All rights reserved.
The separation of structurally diverse analytes is often complicated by chance coelutions with other analytes or with matrix related compounds. Often the column is blamed, but while such coelutions make analysis difficult they do not necessarily indicate a faulty column, poor chromatography or method design.
LC/GC approaches to analysis are attractive because they combine the selectivity of solid-phase sorbents in the first dimension with the separating power and peak capacity of capillary GC in the following dimensions.