Pilar Franco | Authors

Quinine- and quinidine-derived anion-exchanger chiral stationary phases have proven to be versatile in enantiomer separation of acidic compounds in HPLC. In this article, the authors demonstrate their performance in specific HPLC applications involving enantiomer resolution and topoisomer separation.

The development and application of chiral chromatography is described.

Chiral chromatography is now the fastest way to access large amounts of enantiopure pharmaceutical compounds.

The authors describe a study of screening procedures that demonstrated a relatively small set of columns can be used routinely.